TASP 0433864
Tocris Bioscience, part of Bio-Techne | Catalog # 5362
Selective positive allosteric modulator of mGlu2 receptors
Key Product Details
Description
Selective positive allosteric modulator of mGlu2 receptors
Product Description
TASP 0433864 is a selective mGlu2 receptor positive allosteric modulator (EC50 values are 199 and 206 nM for human and rat receptors, respectively). Exhibits negligible activity against a range of neurotransmitter targets, except 5-HT2B and MAO-B (72 and 92% inhibition at 10 μM, respectively). Potentiates inhibitory effect of DCG IV (Cat. No. 0975) on excitatory postsynaptic potentials in hippocampal slices and ketamine- and methamphetamine-induced increases in locomotor activity in rats and mice.Product Specifications
Molecular Weight
329.39
Formula
C18H23N3O3
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
(2S)-2-[[4-(1,1-Dimethylethyl)phenoxy]methyl]-2,3-dihydro-5-methylimidazo[2,1-b]oxazole-6-carboxamide
CAS Number
1431980-60-7
PubChem ID
124201847
InChI Key
IZYYTLCSQBACIP-AWEZNQCLSA-N
SMILES
CC(C)(C)C1=CC=C(OC[C@@H]2CN3C(O2)=NC(C(N)=O)=C3C)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.94 | 100 | |
| Ethanol | 6.59 | 20 |
Preparing Stock Solutions
for TASP 0433864
The following data is based on the product molecular weight 329.39
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.04 mL | 15.18 mL | 30.36 mL |
| 5 mM | 0.61 mL | 3.04 mL | 6.07 mL |
| 10 mM | 0.30 mL | 1.52 mL | 3.04 mL |
| 50 mM | 0.06 mL | 0.30 mL | 0.61 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hiyoshi Neurophysiologic and antipsychotic profiles of TASP0433864, a novel positive allosteric modulator of metabotropic glutamate 2 receptor. J.Pharmacol.Exp.Ther. 2014 PMID: 25277141
Product Specific Notices for TASP 0433864
For research use only
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