TAPI 1

Name: TAPI 1
Brand: Tocris Bioscience
SKU: 6162

Tocris Bioscience, part of Bio-Techne | Catalog # 6162

Citations (17)

COA / SDS

ADAM-17 (TACE) and MMP inhibitor

Key Product Details

Description:	ADAM-17 (TACE) and MMP inhibitor
Chemical Name:	N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl-N-(2-aminoethyl)-L-alaninamide
Purity:	≥95% (HPLC)
Molecular Weight:	499.6

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Technical Data
Citations

Biological Activity for TAPI 1

TAPI 1 is a TACE/ADAM-17 and MMP inhibitor. Blocks shedding of TNF from cell membranes. Reduces pain-associated behavior in mice with a constructive mononeuropathy.

This product is typically reconstituted in DMSO.

Technical Data for TAPI 1

M. Wt	499.6
Formula	C₂₆H₃₇N₅O₅
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	163847-77-6
PubChem ID	9827273
InChi Key	AWNBSWDIOCXWJW-OWHMDLSXSA-N
Smiles	ONC(C[C@@H](CC(C)C)C(N[C@@H](CC1=CC(C=CC=C2)=C2C=C1)C(N[C@@H](C)C(NCCN)=O)=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for TAPI 1

References are publications that support the biological activity of the product.

Mohler Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processing. Nature 1994 PMID: 8028669
Sommer A metalloprotease-inhibitor reduces pain associated behavior in mice with experimental neuropathy. Neurosci. Lett. 1997 PMID: 9406876

TAPI 1

Tocris Bioscience, part of Bio-Techne | Catalog # 6162

Key Product Details

Biological Activity for TAPI 1

Technical Data for TAPI 1

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for TAPI 1

Product Documents for TAPI 1

COA

Certificate of Analysis

SDS

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