TAPI 0 is an ADAM-17 (TACE) and MMP inhibitor; attenuates TNF-α processing. Acts in concert with GM6001 (Cat. No. 2983) to inhibit Chlamydia trachomatis growth.

This product is typically reconstituted in DMSO.

Product Specifications

Molecular Weight

456.54

Formula

C₂₄H₃₂N₄O₅

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl-L-alaninamide

CAS Number

163958-73-4

PubChem ID

3035404

InChI Key

CRCPLBFLOSEABN-VBSNWNEZSA-N

SMILES

ONC(C[C@@H](CC(C)C)C(N[C@@H](CC1=CC(C=CC=C2)=C2C=C1)C(N[C@@H](C)C(N)=O)=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

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Background References

References are publications that support the biological activity of the product.

Rzeniewicz L-selectin shedding is activated specifically within transmigrating pseudopods of monocytes to regulate cell polarity in vitro. Proc.Natl.Acad.Sci.USA. 2015 PMID: 25775539
Balakrishnan Metalloprotease inhibitors GM6001 and TAPI-0 inhibit the obligate intracellular human pathogen Chlamydia trachomatis by targeting peptide deformylase of the bacterium. J.Biol.Chem. 2006 PMID: 16565079

TAPI 0

Tocris Bioscience, part of Bio-Techne | Catalog # 5523

Key Product Details

Description

Alternative Names

View all Matrix Metalloprotease (MMP) Inhibitors »

Product Description