Talniflumate

Name: Talniflumate
Brand: Tocris Bioscience
SKU: 2510
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2510

(1)

COA / SDS

CaCC blocker and Cl-/HCO3- exchange inhibitor

Discontinued Product

2510 has been discontinued. View all Calcium-activated Chloride Channel Blockers products.

Key Product Details

Description:	CaCC blocker and Cl-/HCO3- exchange inhibitor
Chemical Name:	2-[[3-(Trifluoromethyl)phenyl]amino]-1,3-dihydro-3-oxo-1-isobenzofuranyl 3-pyridinecarboxylic acid ester
Purity:	≥99% (HPLC)
Molecular Weight:	414.34

View Full Technical Details for Talniflumate

Technical Data
Citations / Reviews (1)

Biological Activity for Talniflumate

Talniflumate is a calcium-activated chloride channel (CaCC) (hCLCA1/mCLCA3) blocker; reduces mucin synthesis and release in cell culture and animal models. Possesses anti-inflammatory actions via inhibition of cyclooxygenases and inhibits Cl^-/HCO₃^- exchanger activity. Increases survival in a cystic fibrosis mouse model of distal intestinal obstructive syndrome.

Technical Data for Talniflumate

M. Wt	414.34
Formula	C₂₁H₁₃F₃N₂O₄
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	66898-62-2
PubChem ID	48229
InChi Key	ANMLJLFWUCQGKZ-UHFFFAOYSA-N
Smiles	FC(F)(F)C1=CC(NC2=NC=CC=C2C(=O)OC2OC(=O)C3=CC=CC=C23)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Talniflumate

References are publications that support the biological activity of the product.

Sanchez Action of a non-steroidal anti-inflammatory drug on gastric mucosa of rats. J.Appl.Toxicol.
Knight Talniflumate (Genaera). Curr.Opin.Invest.Drugs
Walker Talniflumate increases survival in a cystic fibrosis mouse model of distal intestinal obstructuve syndrome. J.Pharmacol.Exp.Ther. 2006 PMID: 16354791

Talniflumate

Tocris Bioscience, part of Bio-Techne | Catalog # 2510

Key Product Details

Biological Activity for Talniflumate

Technical Data for Talniflumate

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Talniflumate

Product Documents for Talniflumate

COA

Certificate of Analysis

SDS

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