TAK 779
Tocris Bioscience, part of Bio-Techne | Catalog # 4340
Potent and selective CCR5 and CCR2 chemokine receptor antagonist
Key Product Details
Description
Potent and selective CCR5 and CCR2 chemokine receptor antagonist
Product Description
TAK 779 is a potent and selective CCR5 and CCR2 chemokine receptor antagonist (IC50 values = 1 nM and 27 nM, respectively). TAK 779 blocks the binding of macrophage inflammatory protein 1α and 1β to CHO cells (IC50 = 1 nM) and inhibits replication of R5 HIV-1 at 1.6-3.7 nM. In animal models, TAK 779 protects against ischemic brain injury and prevents development of asthma features.Product Specifications
Molecular Weight
531.13
Formula
C33H39N2O2.Cl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[[4-[[[6,7-Dihydro-2-(4-methylphenyl)-5H-benzocyclohepten-8-yl]carbonyl]amino]phenyl]methyl]tetrahydro-N,N-dimethyl-2H-pyran-4-aminium chloride
CAS Number
229005-80-5
PubChem ID
183789
InChI Key
VDALIBWXVQVFGZ-UHFFFAOYSA-N
SMILES
CC1=CC=C(C2=CC(C=C(C(NC3=CC=C(C[N+](C)(C)C4CCOCC4)C=C3)=O)CCC5)=C5C=C2)C=C1.[Cl-]
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 5.31 | 10 | |
| DMSO | 2.66 | 5 |
Preparing Stock Solutions
for TAK 779
The following data is based on the product molecular weight 531.13
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.83 mL | 94.14 mL | 188.28 mL |
| 0.5 mM | 3.77 mL | 18.83 mL | 37.66 mL |
| 1 mM | 1.88 mL | 9.41 mL | 18.83 mL |
| 5 mM | 0.38 mL | 1.88 mL | 3.77 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Suzaki A small-molecule compound targeting CCR5 and CXCR3 prevents airway hyperresponsiveness and inflammation. Eur.Respir.J. 2008 PMID: 18094012
- Takami TAK-779, a nonpeptide CC chemokine receptor antagonist, protects the brain against focal cerebral ischemia in mice. J.Cereb.Blood Flow Metab. 2002 PMID: 12142563
- Baba A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity. Proc.Natl.Acad.Sci.U.S.A. 1999 PMID: 10318947
Product Specific Notices for TAK 779
For research use only
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