TAK 21d
Tocris Bioscience, part of Bio-Techne | Catalog # 5209
Potent FAAH inhibitor
Key Product Details
Description
Potent FAAH inhibitor
Product Description
TAK 21d is a potent FAAH inhibitor; (IC50 values are 0.28 and 0.72 nM, at rat and human FAAH respectively). Displays analgesic effects in vivo models of neuropathic and inflammatory pain. Brain penetrant.Product Specifications
Molecular Weight
397.38
Formula
C19H17F2N7O
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4-[4-(3,4-Difluorophenyl)-2-pyrimidinyl]-N-3-pyridazinyl-1-piperazinecarboxamide
CAS Number
1143578-94-2
PubChem ID
57749996
InChI Key
JCWVFSJNIBAGQN-UHFFFAOYSA-N
SMILES
FC1=CC(C2=NC(N3CCN(C(NC4=CC=CN=N4)=O)CC3)=NC=C2)=CC=C1F
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 7.95 | 20 | |
| DMSO | 3.97 | 10 |
Preparing Stock Solutions
for TAK 21d
The following data is based on the product molecular weight 397.38
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 12.58 mL | 62.91 mL | 125.82 mL |
| 1 mM | 2.52 mL | 12.58 mL | 25.16 mL |
| 2 mM | 1.26 mL | 6.29 mL | 12.58 mL |
| 10 mM | 0.25 mL | 1.26 mL | 2.52 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kono Design, synthesis, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase inhibitors. Bioorg.Med.Chem. 2014 PMID: 24440478
Product Specific Notices for TAK 21d
For research use only
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