TAK 165
Tocris Bioscience, part of Bio-Techne | Catalog # 3599
Potent and selective ErbB2 inhibitor
Key Product Details
Description
Potent and selective ErbB2 inhibitor
Alternative Names
Mubritinib
Product Description
TAK 165 is a potent, irreversible human epithelial growth factor receptor 2 (ErbB2) inhibitor (IC50 = 6 nM) that displays > 4000-fold selectivity over EGFR, FGFR, PDGFR, JAK1 and Src. Exhibits potent antiproliferative effects in ErbB2-overexpressing cancer cell lines (IC50 = 5 nM in BT474 breast cancer cells) and significantly inhibits bladder, breast and prostate cancer xenograft growth in vivo.Product Specifications
Molecular Weight
468.47
Formula
C25H23F3N4O2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
1-[4-[4-[[2-[(1E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-4-oxazolyl]methoxy]phenyl]butyl]-1H-1,2,3-triazole
CAS Number
366017-09-6
PubChem ID
6444692
InChI Key
ZTFBIUXIQYRUNT-MDWZMJQESA-N
SMILES
FC(C(C=C2)=CC=C2/C=C/C1=NC(COC3=CC=C(CCCCN4C=CN=N4)C=C3)=CO1)(F)F
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.14 | 75 |
Preparing Stock Solutions
for TAK 165
The following data is based on the product molecular weight 468.47
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.75 mM | 2.85 mL | 14.23 mL | 28.46 mL |
| 3.75 mM | 0.57 mL | 2.85 mL | 5.69 mL |
| 7.5 mM | 0.28 mL | 1.42 mL | 2.85 mL |
| 37.5 mM | 0.06 mL | 0.28 mL | 0.57 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Nagasawa Novel HER2 selective tyrosine kinase inhibitor, TAK-165, inhibits bladder, kidney and androgen-independent prostate cancer in vitro and in vivo. Int.J.Urol. 2006 PMID: 16771730
- Spector Small molecule HER-2 tyrosine kinase inhibitors. Breast Cancer Res.
- Sridhar Inhibitors of epidermal-growth-factor receptors: a review of clinical research with a focus on non-small-cell lung cancer. Lancet Oncol. 2003 PMID: 12850190
Product Specific Notices for TAK 165
For research use only
Loading...
Loading...