Tadalafil

Name: Tadalafil
Brand: Tocris Bioscience
SKU: 6311

Tocris Bioscience, part of Bio-Techne | Catalog # 6311

Citations (3)

COA / SDS

Potent and highly selective PDE5 inhibitor; orally bioavailable

Key Product Details

Description:	Potent and highly selective PDE5 inhibitor; orally bioavailable
Alternative Names:	GF196960
Chemical Name:	(6R,12aR)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methylpyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione
Purity:	≥98% (HPLC)
Molecular Weight:	389.4

View Full Technical Details for Tadalafil

Technical Data
Citations

Biological Activity for Tadalafil

Tadalafil is a potent and highly selective PDE5 inhibitor (IC₅₀ = 5 nM). Exhibits > 2000-fold selectivity for PDE5 over PDEs 1,2,3 and 4 and 1000-fold selectivity over PDE6. Reduces blood pressure in hypertensive rats. Also delays tumor growth in a mouse model via inhibition of MDSC-mediated immunosuppression. Orally bioavailable.

Compound Libraries for Tadalafil

Tadalafil is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Tadalafil

M. Wt	389.4
Formula	C22H19N3O4
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	171596-29-5
PubChem ID	110635
InChi Key	WOXKDUGGOYFFRN-IIBYNOLFSA-N
Smiles	[H][C@]12CC3=C([C@@H](C4=CC5=C(C=C4)OCO5)N1C(CN(C2=O)C)=O)NC6=CC=CC=C36

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Tadalafil

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	38.94	100

Preparing Stock Solutions for Tadalafil

The following data is based on the product molecular weight 389.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.57 mL	12.84 mL	25.68 mL
5 mM	0.51 mL	2.57 mL	5.14 mL
10 mM	0.26 mL	1.28 mL	2.57 mL
50 mM	0.05 mL	0.26 mL	0.51 mL

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References for Tadalafil

References are publications that support the biological activity of the product.

Serafini Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function. J.Exp.Med. 2006 PMID: 17101732
Daugan The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogues. J.Med.Chem. 2003 PMID: 14521415