TAC

Name: TAC
Brand: Tocris Bioscience
SKU: 8825

Tocris Bioscience, part of Bio-Techne | Catalog # 8825

COA / SDS

TERT activator

Key Product Details

Description:	TERT activator
Chemical Name:	N-(3-Chloro-4-fluorophenyl)-4-fluoro-3,5-dimethylbenzenesulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	331.76

View Full Technical Details for TAC

Technical Data
Citations

Biological Activity for TAC

TAC is a telomerase reverse transcriptase (TERT) activator. TAC upregulates TERT gene transcription via the MEK/ERK/AP-1 cascade. In primary human cells and naturally aged mice, TAC enhances telomere synthesis, reduces tissue aging markers, cellular senescence, and inflammatory cytokines. In the brain, TAC induces neurogenesis, reduces neuroinflammation, and preserves cognitive function.

Technical Data for TAC

M. Wt	331.76
Formula	C₁₄H₁₂ClF₂NO₂S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	666699-46-3
PubChem ID	2805068
InChi Key	JVUSVLUQMXGABO-UHFFFAOYSA-N
Smiles	O=S(NC1=CC=C(C(Cl)=C1)F)(C2=CC(C)=C(F)C(C)=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TAC

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	33.18	100
	ethanol	33.18	100

Preparing Stock Solutions for TAC

The following data is based on the product molecular weight 331.76.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.01 mL	15.07 mL	30.14 mL
5 mM	0.60 mL	3.01 mL	6.03 mL
10 mM	0.30 mL	1.51 mL	3.01 mL
50 mM	0.06 mL	0.30 mL	0.60 mL

Molarity Calculator

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Reconstitution Calculator

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References for TAC

References are publications that support the biological activity of the product.

Shim TERT activation targets DNA methylation and multiple aging hallmarks. Cell 2024 PMID: 38908367

TAC