Tabimorelin hemifumarate
Tocris Bioscience, part of Bio-Techne | Catalog # 2308
Potent, orally active ghrelin receptor agonist
Key Product Details
Description
Potent, orally active ghrelin receptor agonist
Alternative Names
NN 703
Product Description
Tabimorelin hemifumarate is a potent, orally active ghrelin receptor (GHS-R1a) agonist (Ki = 50 nM at human recombinant GHS-R1a). Stimulates GH release from rat pituitary cells with an EC50 value of 2.7 nM. Induces hyperphagia and adiposity in lean rats, but not in leptin signaling-deficient ZDF rats.Product Specifications
Molecular Weight
586.73
Formula
C32H40N4O3.½C4H4O4
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
N-[(2E)-5-Amino-5-methyl-1-oxo-2-hexenyl]-N-methyl-3-(2-naphthalenyl)-D-alanyl-N,Nα-dimethyl-D-phenylalaninamide hemifumarate
CAS Number
242143-80-2
PubChem ID
11981159
InChI Key
YQDJPWXYLLPOPW-LWTUVRFUSA-N
SMILES
[H]OC(=O)\C=C\C(=O)O[H].CNC(=O)[C@@H](CC1=CC=CC=C1)N(C)C(=O)[C@@H](CC1=CC2=CC=CC=C2C=C1)N(C)C(=O)\C=C\CC(C)(C)N.CNC(=O)[C@@H](CC1=CC=CC=C1)N(C)C(=O)[C@@H](CC1=CC2=CC=CC=C2C=C1)N(C)C(=O)\C=C\CC(C)(C)N
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 5.29 | 10 with gentle warming | |
| DMSO | 58.67 | 100 |
Preparing Stock Solutions
for Tabimorelin hemifumarate
The following data is based on the product molecular weight 586.73
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.70 mL | 8.52 mL | 17.04 mL |
| 5 mM | 0.34 mL | 1.70 mL | 3.41 mL |
| 10 mM | 0.17 mL | 0.85 mL | 1.70 mL |
| 50 mM | 0.03 mL | 0.17 mL | 0.34 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Holm Adipogenic and orexigenic effects of the ghrelin-receptor ligand tabimorelin are diminished in leptin-signalling-deficient ZDF rats. Eur.J.Pharmacol. 2004 PMID: 15191361
- Hansen Pharmacological characterisation of a new oral GH secretagogue, NN703. Eur.J.Endocrinol. 1999 PMID: 10427162
Product Specific Notices for Tabimorelin hemifumarate
For research use only
Loading...
Loading...