T4

Product Description

T4 is a modulator of alternative polyadenylation (APA) (IC₅₀ values are 2.1 μM and 8.5 μM in U2OS and 293T cells, respectively). T4 promotes distal-to-proximal APA usage in multiple transcripts, using distinctive A-rich motifs through autoregulated PABPN1 signaling. T4 exhibits no inhibitory activity against a panel of 414 kinases. T4 prevents retinal degeneration in the Rho^P23H mouse model of retinitis pigmentosa. T4 inhibits rod photoreceptor gene expression via Nr2e3 in a luciferase-based assay (IC₅₀ = 0.07 μM).

Solubility

Preparing Stock Solutions for T4

The following data is based on the product molecular weight 377.44

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.02 mM	132.47 mL	662.36 mL	1,324.71 mL
0.1 mM	26.49 mL	132.47 mL	264.94 mL
0.2 mM	13.25 mL	66.24 mL	132.47 mL
1 mM	2.65 mL	13.25 mL	26.49 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Araki Decoding transcriptome dynamics of genome-encoded polyadenylation and autoregulation with small-molecule modulators of alternative polyadenylation. Cell.Chem.Biol. 2018 PMID: 30293940
• Nakamura Small molecule photoregulin3 prevents retinal degeneration in the Rho ^P23H mouse model of retinitis pigmentosa. ELife 2017 PMID: 29148976