T3
Tocris Bioscience, part of Bio-Techne | Catalog # 6666
Thyroid hormone; also promotes differentiation of oligodendroglial precursor cells
Key Product Details
Description
Thyroid hormone; also promotes differentiation of oligodendroglial precursor cells
Product Description
T3 is a thyroid hormone. Promotes differentiation of oligodendroglial precursor cells in neonatal rats and promotes maturation of hiPSC-derived cardiomyocytes. Also specifies cone cell subtype in retinal cell differentiation protocols. T3 is used to generate cortical spheroids and β cells (see protocol below) from hPSCs.T3 synthesized to Ancillary Material Grade also available.
For more information about how T3 may be used, see our protocol: Generation of β cells from hPSCs
Product Specifications
Molecular Weight
650.97
Formula
C15H12I3NO4
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
O-(4-Hydroxy-3-iodophenyl-3,5-diiodo-L-tyrosine
CAS Number
6893-02-3
PubChem ID
5920
InChI Key
AUYYCJSJGJYCDS-LBPRGKRZSA-N
SMILES
N[C@H](C(O)=O)CC1=CC(I)=C(C(I)=C1)OC2=CC(I)=C(C=C2)O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.55 | 50 |
Preparing Stock Solutions
for T3
The following data is based on the product molecular weight 650.97
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.07 mL | 15.36 mL | 30.72 mL |
| 2.5 mM | 0.61 mL | 3.07 mL | 6.14 mL |
| 5 mM | 0.31 mL | 1.54 mL | 3.07 mL |
| 25 mM | 0.06 mL | 0.31 mL | 0.61 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Surendran An improved protocol for generation and characterization of human-induced pluripotent stem cell-derived retinal pigment epithelium cells. STAR Protoc. 2022 PMID: 36386870
- Eldred Thyroid hormone signaling specifies cone subtypes in human retinal organoids. Science 2018 PMID: 30309916
- Madhavan Induction of myelinating oligodendrocytes in human cortical spheroids. Nat Methods. 2018 PMID: 30046099
- Yang Tri-iodo-L-thyronine promotes the maturation of human cardiomyocytes-derived from induced pluripotent stem cells. J.Mol.CellCardiol. 2014 PMID: 24735830
- Marta Sustained neonatal hyperthyroidism in the rat affects myelination in the central nervous system. J.Neurosci.Res. 1998 PMID: 9671982
Product Specific Notices for T3
For research use only
Loading...
Loading...