T 5601640
Tocris Bioscience, part of Bio-Techne | Catalog # 5269
Selective LIMK2 inhibitor; antitumor
Discontinued Product
5269 has been discontinued.
View all LIMK Inhibitors products.
Key Product Details
Description
Selective LIMK2 inhibitor; antitumor
Alternative Names
T56-LIMKi
Product Description
T 5601640 is a selective LIM kinase 2 (LIMK2) inhibitor; inhibits cofilin phosphorylation in cells that overexpress LIMK2 but not LIMK1. Attenuates the growth of several cancer cell lines. Reduces phospho-cofilin levels and Panc-1 tumor size in a mouse xenograft model.Product Specifications
Molecular Weight
389.33
Formula
C19H14F3N3O3
Storage
Store at +4°C
Purity
≥99% (HPLC)
Chemical Name
3-Methyl-N-[3-[[[3-(trifluoromethyl)phenyl]amino]carbonyl]phenyl]-5-isoxazolecarboxamide
CAS Number
924473-59-6
PubChem ID
9438169
InChI Key
XVOKFRPKSAWELK-UHFFFAOYSA-N
SMILES
O=C(C2=CC=CC(NC(C3=CC(C)=NO3)=O)=C2)NC1=CC(C(F)(F)F)=CC=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 19.47 | 50 |
Preparing Stock Solutions
for T 5601640
The following data is based on the product molecular weight 389.33
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.14 mL | 25.69 mL | 51.37 mL |
| 2.5 mM | 1.03 mL | 5.14 mL | 10.27 mL |
| 5 mM | 0.51 mL | 2.57 mL | 5.14 mL |
| 25 mM | 0.10 mL | 0.51 mL | 1.03 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Mashiach-Farkash Computer-based identification of a novel LIMK1/2 inhibitor that synergizes with salirasib to destabilize the actin cytoskeleton. Oncotarget 2012 PMID: 22776759
- Rak Novel LIMK2 inhibitor blocks Panc-1 tumor growth in a mouse xenograft model. Oncoscience 2014 PMID: 25593987
Product Specific Notices for T 5601640
For research use only
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