T 3364366
Tocris Bioscience, part of Bio-Techne | Catalog # 6106
Potent and reversible fatty acid desaturase 1 inhibitor; orally bioavailable
Key Product Details
Description
Potent and reversible fatty acid desaturase 1 inhibitor; orally bioavailable
Product Description
T 3364366 is a potent and reversible fatty acid desaturase 1 (FADS1; Δ5 desaturase) inhibitor (IC50 values are 1.9 nM and 2.1 nM in human and rat hepatocyte cell lines, respectively). Exhibits >300 fold selectivity for FADS1 over FADS2 (Δ6 desaturase). Inhibits arachidonic acid production in rat and human hepatocyte cell lines. Orally bioavailable.Product Specifications
Molecular Weight
443.46
Formula
C18H16F3N3O3S2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-[2-[[3,4-Dihydro-4-oxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]thieno[3,4-d]pyrimidin-2-yl]thio]ethyl]acetamide
CAS Number
1356354-09-0
PubChem ID
86685411
InChI Key
BVRXQXNVDLUWMV-UHFFFAOYSA-N
SMILES
CC(NCCSC1=NC2=CSC=C2C(N1C3=CC=C(C=C3)OCC(F)(F)F)=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.35 | 100 |
Preparing Stock Solutions
for T 3364366
The following data is based on the product molecular weight 443.46
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.25 mL | 11.27 mL | 22.55 mL |
| 5 mM | 0.45 mL | 2.25 mL | 4.51 mL |
| 10 mM | 0.23 mL | 1.13 mL | 2.25 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.45 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Miyahisa T-3364366 targets the desaturase domain of delta-5 desaturase with nanomolar potency and a multihour residence time. ACS Med.Chem.Lett. 2016 PMID: 27660693
Product Specific Notices for T 3364366
For research use only
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