SYM 2081

Name: SYM 2081
Brand: Tocris Bioscience
SKU: 0903

Tocris Bioscience, part of Bio-Techne | Catalog # 0903

Citations (3)

COA / SDS

Highly selective kainate agonist

Discontinued Product

0903 has been discontinued. View all Kainate Receptor Agonists products.

Key Product Details

Description:	Highly selective kainate agonist
Chemical Name:	(2S,4R)-4-Methylglutamic acid
Purity:	≥97% (HPLC)
Molecular Weight:	161.16

View Full Technical Details for SYM 2081

Technical Data
Citations

Biological Activity for SYM 2081

SYM 2081 is a potent and highly selective kainate receptor agonist, with an IC₅₀ for inhibition of [³H]-kainate binding of 35 nM and almost 3,000- and 200-fold selectivity for kainate receptors over AMPA and NMDA receptors respectively. Also selectively inhibits the cloned excitatory amino acid transporter EAAT2 at higher concentrations.

Licensing Information

Sold with the permission of Annovis Inc.

Technical Data for SYM 2081

M. Wt	161.16
Formula	C₆H₁₁NO₄
Storage	Store at RT
Purity	≥97% (HPLC)
CAS Number	31137-74-3
PubChem ID	95883
InChi Key	KRKRAOXTGDJWNI-DMTCNVIQSA-N
Smiles	[H][C@@](N)(C(O)=O)C[C@]([H])([C@](O)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for SYM 2081

References are publications that support the biological activity of the product.

Zhou (2S,4R)-4-Methylglutamic acid (SYM 2081): a selective, high affinity ligand for kainate receptors. J.Pharmacol.Exp.Ther. 1997 PMID: 8996224
Jones Desensitization of kainate receptors by kainate, glutamate and diastereomers of 4-methylglutamate. Neuropharmacology 1997 PMID: 9225313
Savidge Characterisation of kainate receptor mediated whole-cell currents in rat cultured cerebellar granule cells. Neuropharmacology 1999 PMID: 10219975
Donevan The methylglutamate, SYM 2081, is a potent and highly selective agonist at kainate receptors. J.Pharmacol.Exp.Ther. 1998 PMID: 9580595