STF 118804

Tocris Bioscience, part of Bio-Techne | Catalog # 5207

NAMPT inhibitor; depletes leukemia stem cells
Discontinued Product
5207 has been discontinued. View all NAMPT Inhibitors products.

Key Product Details

Description

NAMPT inhibitor; depletes leukemia stem cells

View all NAMPT Inhibitors »

Product Description

STF 118804 is a NAMPT inhibitor (nicotinamide phosphoribosyltransferase, visfatin, PBEF1); inhibits NAD+ synthesis from nicotinamide. Potently inhibits the viability of multiple B-cell acute lymphoplastic leukemia (B-ALL) cell lines (IC50 < 10 nM); induces apoptosis in MF-411 cells. Induces regression of ALL xenografts and eliminates leukemia stems cells from bone marrow in mice.

Product Specifications

Molecular Weight

461.53

Formula

C25H23N3O4S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

4-[5-Methyl-4-[[(4-methylphenyl)sulfonyl]methyl]-2-oxazolyl]-N-(3-pyridinylmethyl)benzamide

CAS Number

894187-61-2

PubChem ID

20916937

InChI Key

DLFCEZOMHBPDGI-UHFFFAOYSA-N

SMILES

O=C(C2=CC=C(C3=NC(CS(C4=CC=C(C)C=C4)(=O)=O)=C(C)O3)C=C2)NCC1=CN=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.15 100

Preparing Stock Solutions for STF 118804

The following data is based on the product molecular weight 461.53

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.17 mL 10.83 mL 21.67 mL
5 mM 0.43 mL 2.17 mL 4.33 mL
10 mM 0.22 mL 1.08 mL 2.17 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for STF 118804

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for STF 118804

For research use only

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