STF 083010

Name: STF 083010
Brand: Tocris Bioscience
SKU: 4509

Tocris Bioscience, part of Bio-Techne | Catalog # 4509

Citations (23)

COA / SDS

Inhibits IRE1α endonuclease activity

Discontinued Product

4509 has been discontinued. View all IRE1 Inhibitors products.

Key Product Details

Description:	Inhibits IRE1α endonuclease activity
Chemical Name:	N-[(2-Hydroxy-1-naphthalenyl)methylene]-2-thiophenesulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	317.38

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Technical Data
Citations

Biological Activity for STF 083010

STF 083010 is a inhibitor of IRE1α endonuclease activity; blocks endogenous XBP1 mRNA splicing. Displays cytostatic and cytotoxic effects in CD138⁺ multiple myeloma (MM) cells in vitro; inhibits bortezomib-induced XBP1 activity in myeloma xenografts in vivo. Does not alter IRE1α kinase activity.

Technical Data for STF 083010

M. Wt	317.38
Formula	C₁₅H₁₁NO₃S₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	307543-71-1
PubChem ID	11487816
InChi Key	RAKGNVNONBJBSW-UHFFFAOYSA-N
Smiles	OC1=CC=C(C=CC=C2)C2=C1/C=N/S(C3=CC=CS3)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for STF 083010

References are publications that support the biological activity of the product.

Kraskiewicz and FitzGerald InterfERing with endoplasmic reticulum stress. Trends Pharmacol.Sci. 2012 PMID: 22112465
Papandreou Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma. Blood. 2011 PMID: 21081713

STF 083010

Tocris Bioscience, part of Bio-Techne | Catalog # 4509

Key Product Details

Biological Activity for STF 083010

Technical Data for STF 083010

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for STF 083010

Product Documents for STF 083010

COA

Certificate of Analysis

SDS

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