STF 083010

Tocris Bioscience, part of Bio-Techne | Catalog # 4509

Inhibits IRE1α endonuclease activity
Discontinued Product
4509 has been discontinued. View all IRE1 Inhibitors products.

Key Product Details

Description

Inhibits IRE1α endonuclease activity

View all IRE1 Inhibitors »

Product Description

STF 083010 is a inhibitor of IRE1α endonuclease activity; blocks endogenous XBP1 mRNA splicing. Displays cytostatic and cytotoxic effects in CD138+ multiple myeloma (MM) cells in vitro; inhibits bortezomib-induced XBP1 activity in myeloma xenografts in vivo. Does not alter IRE1α kinase activity.

Product Specifications

Molecular Weight

317.38

Formula

C15H11NO3S2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-[(2-Hydroxy-1-naphthalenyl)methylene]-2-thiophenesulfonamide

CAS Number

307543-71-1

PubChem ID

11487816

InChI Key

RAKGNVNONBJBSW-UHFFFAOYSA-N

SMILES

OC1=CC=C(C=CC=C2)C2=C1/C=N/S(C3=CC=CS3)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.74 100

Preparing Stock Solutions for STF 083010

The following data is based on the product molecular weight 317.38

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.15 mL 15.75 mL 31.51 mL
5 mM 0.63 mL 3.15 mL 6.30 mL
10 mM 0.32 mL 1.58 mL 3.15 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for STF 083010

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for STF 083010

For research use only

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