Stattic

Name: Stattic
Brand: Tocris Bioscience
SKU: 2798
Rating: 4 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2798

(2)

Citations (124)

COA / SDS

Selective STAT3 inhibitor

Key Product Details

Description:	Selective STAT3 inhibitor
Chemical Name:	6-Nitrobenzo[b]thiophene 1,1-dioxide
Purity:	≥98% (HPLC)
Molecular Weight:	211.19

View Full Technical Details for Stattic

Technical Data
Citations / Reviews (2)

Biological Activity for Stattic

Stattic is a small molecule inhibitor of STAT3. Inhibits binding of tyrosine-phosphorylated peptide motifs to STAT3 SH2 domain and inhibits STAT3 activation, dimerization and nuclear translocation. Displays selectivity over STAT1, STAT5, c-Myc/Max, Jun/Jun and Lck. Induces apoptosis in STAT3-dependent cancer cell lines.

Technical Data for Stattic

M. Wt	211.19
Formula	C₈H₅NO₄S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	19983-44-9
PubChem ID	2779853
InChi Key	ZRRGOUHITGRLBA-UHFFFAOYSA-N
Smiles	O=S2(C1=CC([N+]([O-])=O)=CC=C1C=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Stattic

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	10.56	50

Preparing Stock Solutions for Stattic

The following data is based on the product molecular weight 211.19.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	9.47 mL	47.35 mL	94.70 mL
2.5 mM	1.89 mL	9.47 mL	18.94 mL
5 mM	0.95 mL	4.74 mL	9.47 mL
25 mM	0.19 mL	0.95 mL	1.89 mL

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References for Stattic

References are publications that support the biological activity of the product.

Schust Stattic: a small-molecule inhibitor of STAT3 activation and dimerization. Chem.Biol. 2006 PMID: 17114005