ST 045849
Tocris Bioscience, part of Bio-Techne | Catalog # 6775
O-GlcNAc transferase (OGT) inhibitor
Key Product Details
Description
O-GlcNAc transferase (OGT) inhibitor
Product Description
ST 045849 is an O-GlcNAc transferase (OGT) inhibitor (IC50 = 53 μM). Reduces proliferation and viability of prostate cancer cells in vitro. Depletes intracellular alanine and decreases glucose consumption by cancer cells. Decreases markers of ER stress and apoptosis in pregnant diabetic mice and reduces neural tube defects in embryos from diabetic mice.Product Specifications
Molecular Weight
446.99
Formula
C23H27ClN2O3S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-[(4-Chlorophenyl)imino]tetrahydro-4-oxo-3-(2-tricyclo[3.3.1.13,7]dec-1-ylethyl)-2H-1,3-thiazine-6-carboxylic acid
CAS Number
442665-87-4
PubChem ID
4297469
InChI Key
HLPZEZRNGAXCJH-UHFFFAOYSA-N
SMILES
OC(C1CC(N(/C(S1)=N/C2=CC=C(C=C2)Cl)CCC34CC5CC(C4)CC(C3)C5)=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.7 | 100 | |
| Ethanol | 44.7 | 100 |
Preparing Stock Solutions
for ST 045849
The following data is based on the product molecular weight 446.99
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.24 mL | 11.19 mL | 22.37 mL |
| 5 mM | 0.45 mL | 2.24 mL | 4.47 mL |
| 10 mM | 0.22 mL | 1.12 mL | 2.24 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.45 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kim Impact of protein O-GlcNAcylation on neural tube malformation in diabetic embryopathy. Sci.Rep. 2017 PMID: 28894244
- Kim Versatile O-GlcNAc transferase assay for high-throughput identification of enzyme variants, substrates, and inhibitors. Bioconjug.Chem. 2014 PMID: 24866374
- Itkonen Inhibition of O-GlcNAc transferase activity reprograms prostate cancer cell metabolism. Oncotarget 2016 PMID: 26824323
Product Specific Notices for ST 045849
For research use only
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