SSR 69071
Tocris Bioscience, part of Bio-Techne | Catalog # 2506
Potent, orally active human leukocyte elastase inhibitor
Key Product Details
Description
Potent, orally active human leukocyte elastase inhibitor
Product Description
SSR 69071 is a high affinity, potent inhibitor of human leukocyte elastase (HLE) (IC50 = 3.9 nM). Displays species-selectivity (Ki values are 0.017, 1.70, 3.01, 58 and > 100 nM for human, mouse, rat, rabbit and porcine elastase respectively). Inhibits HLE-induced lung hemorrhage in mice (ID50 = 2.8 mg/kg) and reduces infarct size in an in vivo acute model of coronary ischemia-reperfusion injury. Orally active.Product Specifications
Molecular Weight
556.63
Formula
C27H32N4O7S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
2-[[6-Methoxy-4-(1-methylethyl)-1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl]methoxy]-9-[2-(1-piperidinyl)ethoxy]-4H-pyrido[1,2-a]pyrimidin-4-one
CAS Number
344930-95-6
PubChem ID
9872438
InChI Key
DRZXDZYWZSKFDL-UHFFFAOYSA-N
SMILES
COC1=CC(C(C)C)=C2C(=O)N(COC3=CC(=O)N4C=CC=C(OCCN5CCCCC5)C4=N3)S(=O)(=O)C2=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 13.92 | 25 | |
| Ethanol | 5.57 | 10 |
Preparing Stock Solutions
for SSR 69071
The following data is based on the product molecular weight 556.63
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 7.19 mL | 35.93 mL | 71.86 mL |
| 1.25 mM | 1.44 mL | 7.19 mL | 14.37 mL |
| 2.5 mM | 0.72 mL | 3.59 mL | 7.19 mL |
| 12.5 mM | 0.14 mL | 0.72 mL | 1.44 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Varga A novel orally active inhibitor of HLE. Eur.J.Med.Chem. 2003 PMID: 12750030
- Kapui Biochemical and pharmacological characterization of 2-(9-(2-Piperidinoethoxy)-4-oxo-4H-pyrido[1,2-α]pyrimidin-2-yloxymethyl)-4-(1-methylethyl)-6-methoxy-1,2-benzisothiazol-3(2H)-one-1,1-dioxide (SSR69071), a novel, orally active ela J.Pharmacol.Exp.Ther. 2003 PMID: 12606659
- Bidouard SSR69071, an elastase inhibitor, reduces myocardial infarct size following ischemia-reperfusion injury. Eur.J.Pharmacol. 2003 PMID: 12568915
Product Specific Notices for SSR 69071
For research use only
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