SR 9243

Name: SR 9243
Brand: Tocris Bioscience
SKU: 6138

Tocris Bioscience, part of Bio-Techne | Catalog # 6138

Citations (1)

COA / SDS

Selective LXR inverse agonist

Key Product Details

Description:	Selective LXR inverse agonist
Chemical Name:	N-[2-(3-Bromophenyl)ethyl]-2,4,6-trimethyl-N-[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl]benzenesulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	626.62

View Full Technical Details for SR 9243

Technical Data
Citations

Biological Activity for SR 9243

SR 9243 is a selective LXR inverse agonist. Exhibits no significant activity at other nuclear receptors at maximally effective concentration. Inhibits the Warburg effect and lipogenesis by down-regulation of LXR-mediated gene expression. Selectively reduces cell viability and induces apoptosis in cancer cell lines in vitro. Suppresses hepatic steatosis and inhibits growth of tumor xenografts in mice.

Technical Data for SR 9243

M. Wt	626.62
Formula	C₃₁H₃₂BrNO₄S₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1613028-81-1
PubChem ID	76073169
InChi Key	FYQFEJFTCLKXTQ-UHFFFAOYSA-N
Smiles	CC1=CC(C)=CC(C)=C1S(N(CCC2=CC=CC(Br)=C2)CC(C=C3)=CC=C3C4=CC(S(=O)(C)=O)=CC=C4)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SR 9243

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	12.53	20

Preparing Stock Solutions for SR 9243

The following data is based on the product molecular weight 626.62.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	7.98 mL	39.90 mL	79.79 mL
1 mM	1.60 mL	7.98 mL	15.96 mL
2 mM	0.80 mL	3.99 mL	7.98 mL
10 mM	0.16 mL	0.80 mL	1.60 mL

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References for SR 9243

References are publications that support the biological activity of the product.

Flaveny Broad anti-tumor activity of a small molecule that selectively targets the Warburg effect and lipogenesis. Cancer Cell. 2015 PMID: 26120082