SR 57227 hydrochloride

Name: SR 57227 hydrochloride
Brand: Tocris Bioscience
SKU: 1205
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1205

(1)

Citations (18)

COA / SDS

Potent and selective 5-HT3 agonist

Key Product Details

Description:	Potent and selective 5-HT₃ agonist
Chemical Name:	1-(6-Chloro-2-pyridinyl)-4-piperidinamine hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	248.15

View Full Technical Details for SR 57227 hydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for SR 57227 hydrochloride

SR 57227 hydrochloride is a high affinity, selective 5-HT₃ receptor agonist, active in vivo and CNS penetrant.

Technical Data for SR 57227 hydrochloride

M. Wt	248.15
Formula	C₁₀H₁₄ClN₃.HCl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	77145-61-0
PubChem ID	131746
InChi Key	FUMINTAAUJUVMP-UHFFFAOYSA-N
Smiles	Cl.NC1CCN(CC1)C1=NC(Cl)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SR 57227 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	24.82	100
	DMSO	24.82	100

Preparing Stock Solutions for SR 57227 hydrochloride

The following data is based on the product molecular weight 248.15.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.03 mL	20.15 mL	40.30 mL
5 mM	0.81 mL	4.03 mL	8.06 mL
10 mM	0.40 mL	2.01 mL	4.03 mL
50 mM	0.08 mL	0.40 mL	0.81 mL

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Reconstitution Calculator

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References for SR 57227 hydrochloride

References are publications that support the biological activity of the product.

Edwards 5-HT₃-like receptors in the rat medial prefrontal cortex: further pharmacological characterization. Brain Res. 1996 PMID: 8891244
Bachy SR 57227A: a potent and selective agonist at central and peripheral 5-HT₃ receptors in vitro and in vivo. Eur.J.Pharmacol. 1993 PMID: 7689975