SR 3576
Tocris Bioscience, part of Bio-Techne | Catalog # 5044
Highly potent and selective JNK3 inhibitor
Key Product Details
Description
Highly potent and selective JNK3 inhibitor
Product Description
SR 3576 is a highly potent and selective JNK3 inhibitor (IC50 = 7 nM); exhibits > 2800-fold selectivity over p38.Product Specifications
Molecular Weight
501.53
Formula
C27H27N5O5
Storage
Store at -20°C
Purity
≥97% (HPLC)
Chemical Name
3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)benzamide
CAS Number
1164153-22-3
PubChem ID
70702008
InChI Key
MTFAYLZZDJGFGV-UHFFFAOYSA-N
SMILES
O=C(NC3=CC(OC)=C(OC)C(OC)=C3)C1=CC=CC(N2C=C(NC(NC4=CC=CC(C)=C4)=O)C=N2)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 50.15 | 100 |
Preparing Stock Solutions
for SR 3576
The following data is based on the product molecular weight 501.53
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.99 mL | 9.97 mL | 19.94 mL |
| 5 mM | 0.40 mL | 1.99 mL | 3.99 mL |
| 10 mM | 0.20 mL | 1.00 mL | 1.99 mL |
| 50 mM | 0.04 mL | 0.20 mL | 0.40 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kamenecka Structure-activity relationships and X-ray structures describing the selectivity of aminopyrazole inhibitors for c-Jun N-terminal kinase 3 (JNK3) over p38. J Biol Chem. 2009 PMID: 19261605
Product Specific Notices for SR 3576
For research use only
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