SR 2211

Name: SR 2211
Brand: Tocris Bioscience
SKU: 4869

Tocris Bioscience, part of Bio-Techne | Catalog # 4869

Citations (18)

COA / SDS

Selective RORγ inverse agonist

Key Product Details

Description:	Selective RORγ inverse agonist
Chemical Name:	2-Fluoro-4'-[[4-(4-pyridinylmethyl)-1-piperazinyl]methyl]-a,a-bis(trifluoromethyl)-[1,1'-biphenyl]-4-methanol
Purity:	≥98% (HPLC)
Molecular Weight:	527.48

View Full Technical Details for SR 2211

Technical Data
Citations

Biological Activity for SR 2211

SR 2211 is a selective inverse agonist of retinoic acid receptor-related orphan receptor γ (RORγ) (K_i = 105 nM; IC₅₀ ~320 nM). Exhibits weak activity at liver X receptor α (LXRα); does not affect the transcriptional activity of farnesoid X receptors (FXR), and has no impact on the transcriptional activity of RORα.

Licensing Information

Sold under license from The Scripps Research Institute.

Compound Libraries for SR 2211

SR 2211 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SR 2211

M. Wt	527.48
Formula	C₂₆H₂₄F₇N₃O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1359164-11-6
PubChem ID	51035449
InChi Key	KVHKWAZUPPBMLL-UHFFFAOYSA-N
Smiles	FC(C=C(C(O)(C(F)(F)F)C(F)(F)F)C=C4)=C4C(C=C3)=CC=C3CN(CC2)CCN2CC1=CC=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SR 2211

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	52.75	100

Preparing Stock Solutions for SR 2211

The following data is based on the product molecular weight 527.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.90 mL	9.48 mL	18.96 mL
5 mM	0.38 mL	1.90 mL	3.79 mL
10 mM	0.19 mL	0.95 mL	1.90 mL
50 mM	0.04 mL	0.19 mL	0.38 mL

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References for SR 2211

References are publications that support the biological activity of the product.

Kumar Identification of SR2211: a potent synthetic RORγ-selective modulator. ACS Chem.Biol. 2012 PMID: 22292739