SR 16832
Tocris Bioscience, part of Bio-Techne | Catalog # 6383
Dual site PPARγ inhibitor
Key Product Details
Description
Dual site PPARγ inhibitor
Product Description
SR 16832 is a dual site PPARγ inhibitor. Acts at orthosteric and allosteric sites in the ligand binding domain. Inhibits binding of endogenous ligands and transcriptional activity of PPARγ, more effectively than the orthosteric covalent antagonists GW 9662 (Cat. No. 1508) and T 0070907 (Cat. No. 2301).Product Specifications
Molecular Weight
357.75
Formula
C17H12ClN3O4
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
2-Chloro-N-(6-methoxy-4-quinolinyl)-5-nitrobenzamide
CAS Number
2088135-12-8
PubChem ID
134160241
InChI Key
CVTZAGCRUDYUGB-UHFFFAOYSA-N
SMILES
COC1=CC2=C(N=CC=C2NC(C3=CC([N+]([O-])=O)=CC=C3Cl)=O)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 17.89 | 50 |
Preparing Stock Solutions
for SR 16832
The following data is based on the product molecular weight 357.75
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.59 mL | 27.95 mL | 55.90 mL |
| 2.5 mM | 1.12 mL | 5.59 mL | 11.18 mL |
| 5 mM | 0.56 mL | 2.80 mL | 5.59 mL |
| 25 mM | 0.11 mL | 0.56 mL | 1.12 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Brust Modification of the othosteric PPARγ covalent antagonist scaffold yields an improved dual-site allosteric inhibitor. ACS Chem.Biol. 2017 PMID: 28165718
Product Specific Notices for SR 16832
For research use only
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