SR 16584
Tocris Bioscience, part of Bio-Techne | Catalog # 4424
Selective α3β4 nAChR antagonist
Key Product Details
Description
Selective α3β4 nAChR antagonist
Product Description
SR 16584 is a selective α3β4 nAChR antagonist (IC50 = 10.2 μM). Selectively binds α3β4 over α4β2 and α7 subtypes (Ki values are 0.508, >100 and >100 μM, respectively).Product Specifications
Molecular Weight
270.37
Formula
C17H22N2O
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
1,3-Dihydro-1-(3-exo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-2H-indol-2-one
CAS Number
1150153-86-8
PubChem ID
42602880
InChI Key
GIDZCNCCCWFCIN-UHFFFAOYSA-N
SMILES
O=C(CC3=C2C=CC=C3)N2[C@H]1C[C@@H](N4C)CCC[C@@H]4C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.04 | 100 |
Preparing Stock Solutions
for SR 16584
The following data is based on the product molecular weight 270.37
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.70 mL | 18.49 mL | 36.99 mL |
| 5 mM | 0.74 mL | 3.70 mL | 7.40 mL |
| 10 mM | 0.37 mL | 1.85 mL | 3.70 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.74 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Zaveri Novel α3β4 nicotinic acetylcholine receptor-selective ligands. Discovery, structure-activity studies, and pharmacological evaluation. J.Med.Chem. 2012 PMID: 20979364
Product Specific Notices for SR 16584
For research use only
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