SR 141716A

Tocris Bioscience, part of Bio-Techne | Catalog # 0923

Selective CB1 inverse agonist
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Key Product Details

Description

Selective CB1 inverse agonist

Alternative Names

Rimonabant hydrochloride

View all Cannabinoid R1/CB1 Inverse Agonists »

Product Description

SR 141716A is a potent and selective cannabinoid CB1 receptor antagonist (Ki = 1.98 nM). Also acts as an inverse agonist reversing adenylyl cyclase inhibition by WIN 55,212-2 (Cat.No. 1038) (IC50 = 48 nM). Displays no activity at CB2 receptors. Reduces food intake and body weight in orally dosed non-obese Wistar rats. Also μ-opioid receptor antagonist (Ki = 652 nm)

Product Specifications

Molecular Weight

500.25

Formula

C22H21Cl3N4O.HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

N-(Piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide hydrochloride

CAS Number

158681-13-1

PubChem ID

104849

InChI Key

REOYOKXLUFHOBV-UHFFFAOYSA-N

SMILES

O=C(NN4CCCCC4)C1=NN(C3=CC=C(Cl)C=C3Cl)C(C2=CC=C(Cl)C=C2)=C1C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 50.02 100

Preparing Stock Solutions for SR 141716A

The following data is based on the product molecular weight 500.25

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.00 mL 10.00 mL 19.99 mL
5 mM 0.40 mL 2.00 mL 4.00 mL
10 mM 0.20 mL 1.00 mL 2.00 mL
50 mM 0.04 mL 0.20 mL 0.40 mL

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Product Documents for SR 141716A

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SR 141716A

For research use only

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