SR 11237
Tocris Bioscience, part of Bio-Techne | Catalog # 3411
Pan RXR agonist
Key Product Details
Description
Pan RXR agonist
Alternative Names
BMS 649
Product Description
SR 11237 is a pan retinoid X receptor (RXR) agonist that is devoid of any RAR activity.Product Specifications
Molecular Weight
380.48
Formula
C24H28O4
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dioxolan-2-yl]-benzoic acid
CAS Number
146670-40-8
PubChem ID
127019
InChI Key
ZZUKALQMHNSWTK-UHFFFAOYSA-N
SMILES
CC1(C)C2=C(C=CC(C4(OCCO4)C3=CC=C(C(O)=O)C=C3)=C2)C(C)(C)CC1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.05 | 100 |
Preparing Stock Solutions
for SR 11237
The following data is based on the product molecular weight 380.48
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.63 mL | 13.14 mL | 26.28 mL |
| 5 mM | 0.53 mL | 2.63 mL | 5.26 mL |
| 10 mM | 0.26 mL | 1.31 mL | 2.63 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.53 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Benoit RAR-independent RXR signaling induces t(15;17) leukemia cell maturation. EMBO J. 1999 PMID: 10601023
- Zhou Retinoid X receptor agonists inhibit phorbol-12-myristate-13-acetate (PMA)-induced differentiation of monocytic THP-1 cells into macrophages. Mol.Cell.Biochem. 2010 PMID: 19784811
- Chiba Distinct retinoid X receptor-retinoic acid receptor heterodimers are differentially involved in the control of expression of retinoid target genes in F9 embryonal carcinoma cells. Mol.Cell.Biol. 1997 PMID: 9154799
Product Specific Notices for SR 11237
For research use only
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