SR 10067

Product Description

SR 10067 is a selective Rev-Erbα/β agonist (IC₅₀ values are 160 and 170 nM for Rev-Erbβ and Rev-Erbα respectively). Exhibits no significant activity against a wide range of nuclear receptors, other receptors, ion channels and transporters at 20 μM. Increases wakefulness, reduces REM and slow wave sleep in vivo. Also reduces anxiety-like behavior in marble-burying assay. Cell permeable and brain penetrant.

Solubility

Preparing Stock Solutions for SR 10067

The following data is based on the product molecular weight 465.58

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	42.96 mL	214.79 mL	429.57 mL
0.25 mM	8.59 mL	42.96 mL	85.91 mL
0.5 mM	4.30 mL	21.48 mL	42.96 mL
2.5 mM	0.86 mL	4.30 mL	8.59 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Thevis Emerging drugs affecting skeletal muscle function and mitochondrial biogenesis - Potential implications for sports drug testing programs. Rapid Commun. Mass Spectrom 2016 PMID: 26842585
• Banerjee Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behaviour. Nat.Commun. 2014 PMID: 25536025