SR 0987
Tocris Bioscience, part of Bio-Techne | Catalog # 5868
T cell-specific RORγ (RORγt) agonist
Key Product Details
Description
T cell-specific RORγ (RORγt) agonist
Product Description
SR 0987 is a T cell-specific RORγ (RORγt) agonist (EC50 = 800 nM in a gene reporter assay). Induces IL-17 expression and decreases PD-1 expression in T cells in vitro.Product Specifications
Molecular Weight
397.70
Formula
C16H10ClF6NO2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
2-Chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzamide
CAS Number
303126-97-8
PubChem ID
2323435
InChI Key
IZVBONMVWLTLNT-UHFFFAOYSA-N
SMILES
OC(C(F)(F)F)(C(F)(F)F)C1=CC=C(C=C1)NC(C2=C(C=CC=C2)Cl)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.77 | 100 | |
| Ethanol | 39.77 | 100 |
Preparing Stock Solutions
for SR 0987
The following data is based on the product molecular weight 397.70
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.51 mL | 12.57 mL | 25.14 mL |
| 5 mM | 0.50 mL | 2.51 mL | 5.03 mL |
| 10 mM | 0.25 mL | 1.26 mL | 2.51 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.50 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Chang Synthetic RORγt agonists enhance protective immunity. ACS Chem.Biol. 2016 PMID: 26785144
Product Specific Notices for SR 0987
For research use only
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