SQ 22536
Tocris Bioscience, part of Bio-Techne | Catalog # 1435
Adenylyl cyclase inhibitor
Product Description
SQ 22536 is an inhibitor of adenylyl cyclase (IC50 = 1.4 μM). Inhibits PGE1-stimulated increases in cAMP levels in intact human platelets. Cell permeable.Product Specifications
Molecular Weight
205.22
Formula
C9H11N5O
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
9-(Tetrahydro-2-furanyl)-9H-purin-6-amine
CAS Number
17318-31-9
PubChem ID
5270
InChI Key
UKHMZCMKHPHFOT-UHFFFAOYSA-N
SMILES
NC1=C2N=CN(C3CCCO3)C2=NC=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 10.26 | 50 |
Preparing Stock Solutions
for SQ 22536
The following data is based on the product molecular weight 205.22
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 9.75 mL | 48.73 mL | 97.46 mL |
| 2.5 mM | 1.95 mL | 9.75 mL | 19.49 mL |
| 5 mM | 0.97 mL | 4.87 mL | 9.75 mL |
| 25 mM | 0.19 mL | 0.97 mL | 1.95 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Madhavan Induction of myelinating oligodendrocytes in human cortical spheroids. Nat.Methods. 2018 PMID: 30046099
- Mei Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis. Nat.Methods. 2014 PMID: 24997607
- Harris Inhibition of adenylate cyclase in human blood platelets by 9-substituted adenine derivatives. J.Cyclic Nucleotide Res. 1979 PMID: 221552
- Hourani Role of cyclic nucleotides in vasodilations of the rat thoracic aorta induced by adenosine analogues. Br.J.Pharmacol. 2001 PMID: 11454656
- Fabbri Inhibition of adenylate cyclase of catfish and rat hepatocyte membranes by 9-(tetrahydro-2-furyl)adenine (SQ 22536). J.Enzyme Inhib. 1991 PMID: 1669444
Product Specific Notices for SQ 22536
For research use only
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