SPT Imidazopyridine 1
Tocris Bioscience, part of Bio-Techne | Catalog # 6055
Potent serine palmitoyl transferase inhibitor
Key Product Details
Description
Potent serine palmitoyl transferase inhibitor
Product Description
SPT Imidazopyridine 1 is a potent serine palmitoyl transferase (SPT) inhibitor (IC50 = 5 nM). Dose-dependently inhibits incorporation of 14C-serine into ceramide. Reduces plasma ceramide levels in vivo. Also increases plasma HDL and reduces vLDL cholesterol levels in rats.Product Specifications
Molecular Weight
364.44
Formula
C22H24N2O3
Storage
Store at +4°C
Purity
≥98%
Chemical Name
4-[6-(1-Oxoheptyl)imidazo[1,2-a]pyridin-8-yl]benzeneacetic acid
CAS Number
1933533-18-6
PubChem ID
131954583
InChI Key
MMYRYMMKMUTPBB-UHFFFAOYSA-N
SMILES
CCCCCCC(C1=CN2C=CN=C2C(C3=CC=C(C=C3)CC(O)=O)=C1)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.44 | 100 |
Preparing Stock Solutions
for SPT Imidazopyridine 1
The following data is based on the product molecular weight 364.44
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.74 mL | 13.72 mL | 27.44 mL |
| 5 mM | 0.55 mL | 2.74 mL | 5.49 mL |
| 10 mM | 0.27 mL | 1.37 mL | 2.74 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.55 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Genin Imidazopyridine and pyrazolopiperidine derivatives as novel inhibitors of serine palmitoyl transferase. J.Med.Chem. 2016 PMID: 27213958
Product Specific Notices for SPT Imidazopyridine 1
For research use only
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