Spironolactone

Tocris Bioscience, part of Bio-Techne | Catalog # 2968

Mineralocorticoid receptor antagonist
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Key Product Details

Description

Mineralocorticoid receptor antagonist

Alternative Names

SC 9420,Aldactone

View all Mineralocorticoid Receptor Antagonists »

Product Description

Spironolactone is a competitive mineralocorticoid (aldosterone) receptor antagonist that exhibits antihypertensive activity in vivo. Also displays antiandrogen activity and inhibits steroid hormone biosynthesis.

Product Specifications

Molecular Weight

416.57

Formula

C24H32O4S

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

(7α,17α)-7-(Acetylthio)-17-hydroxy-3-oxopregn-4-ene-21-carboxylic acid γ-lactone

CAS Number

52-01-7

PubChem ID

5833

InChI Key

LXMSZDCAJNLERA-ZHYRCANASA-N

SMILES

O=C1CC[C@@]2(C)C(C[C@@H](SC(C)=O)[C@]3([H])[C@@]([H])2CC[C@@]4(C)[C@]([H])3CC[C@@]54OC(CC5)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.66 100
Ethanol 20.83 50

Preparing Stock Solutions for Spironolactone

The following data is based on the product molecular weight 416.57

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.40 mL 12.00 mL 24.01 mL
5 mM 0.48 mL 2.40 mL 4.80 mL
10 mM 0.24 mL 1.20 mL 2.40 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

Calculators

Molarity Calculator

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Dilution Calculator

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for Spironolactone

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Spironolactone

For research use only

⚠ WARNING: This product can expose you to chemicals including Spironolactone, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
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