Spexin

Tocris Bioscience, part of Bio-Techne | Catalog # 6090

COA / SDS

Potent GAL2/3 agonist; exhibits anxiolytic effects in vivo

Key Product Details

Description:	Potent GAL_2/3 agonist; exhibits anxiolytic effects in vivo
Alternative Names:	NPQ,Neuropeptide Q
Purity:	≥95% (HPLC)
Molecular Weight:	1619.9

View Full Technical Details for Spexin

Technical Data
Citations

Biological Activity for Spexin

Spexin is a potent galanin receptor 2/3 (GAL₂/GAL₃) agonist (EC₅₀ values are 45.7 and 112.2 nM, respectively). Exhibits no significant activity at galanin receptor 1. Endogenous satiety-inducing peptide; inhibits long chain fatty acid uptake by adipocytes and decreases food consumption in diet-induced obese mice and rats. Attenuates LH secretion in goldfish. Exhibits anxiolytic effects in vivo.

Technical Data for Spexin

M. Wt	1619.9
Formula	C₇₄H₁₁₄N₂₀O₁₉S
Single Letter Sequence	NWTPQAMLYLKGAQ (Modifications: Gln-14 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	1370290-58-6
PubChem ID	122705996
InChi Key	ZZDZBDJTNIOJMF-TWMPYRTRSA-N
Smiles	[H]N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Spexin

Solubility

Soluble to 1mg/ml in water

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References for Spexin

References are publications that support the biological activity of the product.

Reyes-Alcaraz Development of spexin-based human galanin receptor type II-specific agonists with increased stability in serum and anxiolytic effect in mice. Sci.Rep. 2016 PMID: 26907960
Kim Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III. Endocrinology 2014 PMID: 24517231
Walewski Spexin is a novel human peptide that reduces adipocyte uptake of long chain fatty acids and causes weight loss in rodents with diet-induced obesity Obesity (Silver Spring) 2014 PMID: 24550067