SP 100030

Name: SP 100030
Brand: Tocris Bioscience
SKU: 5309
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 5309

Citations (8)

COA / SDS

NF-κB and AP-1 dual inhibitor

Key Product Details

Description:	NF-κB and AP-1 dual inhibitor
Chemical Name:	N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	437.65

View Full Technical Details for SP 100030

Technical Data
Citations

Biological Activity for SP 100030

SP 100030 is a potent dual inhibitor of NF-κB and AP-1 transcriptional activity (IC₅₀ = 50 nM). Blocks production of IL-2, IL-8 and TNF-α from Jurkat T cells. Inhibits cytokine production selectively in T cells; exhibits minimal inhibition of cytokine production in other cell types. Decreases arthritic severity in a mouse model of collagen-induced arthritis. Also ameliorates muscle wasting in a rat model of cancer cachexia.

Compound Libraries for SP 100030

SP 100030 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for SP 100030

M. Wt	437.65
Formula	C₁₄H₅ClF₉N₃O
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	154563-54-9
PubChem ID	9910975
InChi Key	GHMKQBWHPQMXSH-UHFFFAOYSA-N
Smiles	O=C(NC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)C1=C(C(F)(F)F)N=C(Cl)N=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SP 100030

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	43.76	100
	ethanol	43.76	100

Preparing Stock Solutions for SP 100030

The following data is based on the product molecular weight 437.65.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.28 mL	11.42 mL	22.85 mL
5 mM	0.46 mL	2.28 mL	4.57 mL
10 mM	0.23 mL	1.14 mL	2.28 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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References for SP 100030

References are publications that support the biological activity of the product.

Sullivan 2-Chloro-4-(trifluoromethyl)pyrimidine-5-N-(3',5'- bis(trifluoromethyl)phenyl)-carboxamide: a potent inhibitor of NF-κB- and AP-1-mediated gene expression identified using solution-phase combinatorial ch J.Med.Chem. 1998 PMID: 9484492
Moore-Carrasco The AP-1/NF-κB double inhibitor SP100030 can revert muscle wasting during experimental cancer cachexia. Int.J.Oncol. 2007 PMID: 17390027
Gerlag The effect of a T cell-specific NF-κB inhibitor on in vitro cytokine production and collagen-induced arthritis J.Immunol. 2000 PMID: 10903776