SNS 314 mesylate

Name: SNS 314 mesylate
Brand: Tocris Bioscience
SKU: 4584

Tocris Bioscience, part of Bio-Techne | Catalog # 4584

COA / SDS

Potent pan-Aurora kinase inhibitor

Discontinued Product

4584 has been discontinued. View all Aurora Kinase Inhibitors products.

Key Product Details

Description:	Potent pan-Aurora kinase inhibitor
Chemical Name:	N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea methanesulfonate
Purity:	≥98% (HPLC)
Molecular Weight:	527.04

View Full Technical Details for SNS 314 mesylate

Technical Data
Citations

Biological Activity for SNS 314 mesylate

SNS 314 mesylate is a potent, ATP-competitive Aurora kinase inhibitor (IC₅₀ values are 3, 9 and 31 nM for Aurora C, A and B, respectively). Exhibits both in vitro and in vivo activity against human cancer cell lines and tumor xenograft models. Displays additive antiproliferative effects in combination with chemotherapeutics such as carboplatin (Cat. No. 2626), gemcitabine (Cat. No. 3259) and 5-fluorouracil (Cat. No. 3257).

Technical Data for SNS 314 mesylate

M. Wt	527.04
Formula	C₁₈H₁₅ClN₆OS₂.CH₃SO₃H
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1146618-41-8
PubChem ID	24995523
InChi Key	FYCODPVDEFFWSR-UHFFFAOYSA-N
Smiles	O=C(NC4=CC(Cl)=CC=C4)NC3=NC=C(S3)CCNC1=NC=NC2=C1SC=C2.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for SNS 314 mesylate

References are publications that support the biological activity of the product.

VanderPorten The Aurora kinase inhibitor SNS-314 shows broad therapeutic potential with chemotherapeutics and synergy with microtubule-targeted agents in a colon carcinoma model. Mol.Cancer Ther. 2009 PMID: 19372566
Oslob Discovery of a potent and selective Aurora kinase inhibitor. Bioorg.Med.Chem.Lett. 2008 PMID: 18678489
Arbitrario SNS-314, a pan-Aurora kinase inhibitor, shows potent and anti-tumor activity and dosing flexibility in vivo. Cancer Chemother. Pharmacol. 2010 PMID: 19649632

SNS 314 mesylate

Tocris Bioscience, part of Bio-Techne | Catalog # 4584

Key Product Details

Biological Activity for SNS 314 mesylate

Technical Data for SNS 314 mesylate

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for SNS 314 mesylate

Product Documents for SNS 314 mesylate

COA

Certificate of Analysis

SDS

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