SMIFH2
Tocris Bioscience, part of Bio-Techne | Catalog # 4401
FH2 domain inhibitor; prevents actin nucleation
Discontinued Product
4401 has been discontinued.
View all Actin-related Products products.
Key Product Details
Description
FH2 domain inhibitor; prevents actin nucleation
Product Description
SMIFH2 is an inhibitor of formin homology 2 (FH2) domains. Prevents formin-mediated actin nucleation and barbed end elongation. Disrupts formin-dependent actin cytoskeletal structures in fission yeast and mammalian NIH 3T3 fibroblasts.Product Specifications
Molecular Weight
377.21
Formula
C15H9BrN2O3S
Storage
Store at +4°C
Purity
≥99% (HPLC)
Chemical Name
1-(3-Bromophenyl)-5-(2-furanylmethylene)dihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione
CAS Number
340316-62-3
PubChem ID
2258538
InChI Key
MVFJHEQDISFYIS-XYOKQWHBSA-N
SMILES
O=C(/C(C(N2)=O)=C/C1=CC=CO1)N(C3=CC=CC(Br)=C3)C2=S
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.72 | 100 |
Preparing Stock Solutions
for SMIFH2
The following data is based on the product molecular weight 377.21
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.65 mL | 13.26 mL | 26.51 mL |
| 5 mM | 0.53 mL | 2.65 mL | 5.30 mL |
| 10 mM | 0.27 mL | 1.33 mL | 2.65 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.53 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Poincloux Contractility of the cell rear drives invasion of breast tumor cells in 3D Matrigel. Proc.Natl.Acad.Sci.USA 2011 PMID: 21245302
- Rizvi Identification and characterization of a small molecule inhibitor of formin-mediated actin assembly. Chem.Biol. 2009 PMID: 19942139
Product Specific Notices for SMIFH2
For research use only
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