SLU-PP-332

Name: SLU-PP-332
Brand: Tocris Bioscience
SKU: 8112

Tocris Bioscience, part of Bio-Techne | Catalog # 8112

COA / SDS

Potent pan-ERR agonist

Key Product Details

Description:	Potent pan-ERR agonist
Chemical Name:	(E)-4-Hydroxy-N'-(naphthalen-2-ylmethylene)benzohydrazide
Purity:	≥98% (HPLC)
Molecular Weight:	290.32

View Full Technical Details for SLU-PP-332

Technical Data
Citations

Biological Activity for SLU-PP-332

SLU-PP-332 is a potent and selective pan estrogen related receptor (ERR) agonist (EC₅₀ values are 98 nM, 230 nM and 430 nM for ERRα, ERRβ and ERRγ respectively). In a mouse model of metabolic syndrome SLU-PP-332 increases energy expenditure and fatty acid oxidation, decreases fat mass, and improves insulin sensitivity. Also increases mitochondrial respiration in vitro.

Technical Data for SLU-PP-332

M. Wt	290.32
Formula	C₁₈H₁₄N₂O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	303760-60-3
PubChem ID	5404083
InChi Key	RNZIMBFHRXYRLL-XDHOZWIPSA-N
Smiles	O=C(C1=CC=C(C=C1)O)N/N=C/C2=CC3=C(C=CC=C3)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SLU-PP-332

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	29.03	100

Preparing Stock Solutions for SLU-PP-332

The following data is based on the product molecular weight 290.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.44 mL	17.22 mL	34.44 mL
5 mM	0.69 mL	3.44 mL	6.89 mL
10 mM	0.34 mL	1.72 mL	3.44 mL
50 mM	0.07 mL	0.34 mL	0.69 mL

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References for SLU-PP-332

References are publications that support the biological activity of the product.

Billon A synthetic ERR agonist alleviates metabolic syndrome. J.Pharmacol.Exp.Ther. 2024 PMID: 37739806
Billon Synthetic ERRα/β/γ agonist induces an ERRα-dependent acute aerobic exercise response and enhances exercise capacity. ACS Chem.Biol. 2023 PMID: 36988910