SKLB-11A New
Tocris Bioscience, part of Bio-Techne | Catalog # 8979
Potent and selective SIRT3 allosteric activator
Key Product Details
Description
Potent and selective SIRT3 allosteric activator
Product Description
SKLB-11A is a potent and selective allosteric activator of SIRT3 (Kd = 4.7 μM), enhancing its deacetylation activity (EC50 = 22 μM). SKLB-11A showed no binding to SIRT5 or SIRT6, and low binding affinity for SIRT1 and SIRT2 (Kd values exceeded 200 μM, 40 times lower than its affinity for SIRT3).In vitro and in vivo, SKLB-11A induces autophagy, leading to cardioprotective efficacy.
Product Specifications
Molecular Weight
350.35
Formula
C19H15FN4O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
Methyl 2-amino-1-[(4-fluorophenyl)methyl]-1H-pyrrolo[2,3-b]quinoxaline-3-carboxylate
CAS Number
433953-86-7
PubChem ID
987502
InChI Key
ZIRBXDWXWABLAI-UHFFFAOYSA-N
SMILES
O=C(C1=C(N)N(CC2=CC=C(C=C2)F)C3=C1N=C4C=CC=CC4=N3)OC
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 7.01 | 20 with gentle warming |
Preparing Stock Solutions
for SKLB-11A
The following data is based on the product molecular weight 350.35
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 14.27 mL | 71.36 mL | 142.71 mL |
| 1 mM | 2.85 mL | 14.27 mL | 28.54 mL |
| 2 mM | 1.43 mL | 7.14 mL | 14.27 mL |
| 10 mM | 0.29 mL | 1.43 mL | 2.85 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Zhang Unraveling small molecule-mediated sirtuin 3 activation at a distinct binding site for cardioprotective therapies. ACS Cent.Sci. 2025 PMID: 40454347
Product Specific Notices for SKLB-11A
For research use only
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