SKF 81297 hydrobromide
Tocris Bioscience, part of Bio-Techne | Catalog # 1447
D1 agonist
Product Description
SKF 81297 hydrobromide is a dopamine D1-like receptor agonist. Centrally active following systemic administration in vivo.Product Specifications
Molecular Weight
370.67
Formula
C16H16ClNO2.HBr
Storage
Desiccate at +4°C
Purity
≥98% (HPLC)
Chemical Name
(±)-6-Chloro-2,3,4,5-tetrahydro-1-phenyl-1H-3-benzazepine hydrobromide
CAS Number
67287-39-2
PubChem ID
11957706
InChI Key
RMIJGBMRNYUZRG-UHFFFAOYSA-N
SMILES
Br.OC1=C(O)C(Cl)=C2CCNCC(C3=CC=CC=C3)C2=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 3.71 | 10 with gentle warming | |
| DMSO | 37.07 | 100 |
Preparing Stock Solutions
for SKF 81297 hydrobromide
The following data is based on the product molecular weight 370.67
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.70 mL | 13.49 mL | 26.98 mL |
| 5 mM | 0.54 mL | 2.70 mL | 5.40 mL |
| 10 mM | 0.27 mL | 1.35 mL | 2.70 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.54 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Peacock The effects of DA D1 and D2 receptor agonists and antagonists in monkeys withdrawn from long-term neuroleptic treatment. Eur.J.Pharmacol. 1990 PMID: 1980891
- Reavill Pharmacological characterization of the discriminative stimulus properties of the DA D1 agonist, SKF 81297. Behav.Pharmacol. 1993 PMID: 11224180
- Arnt Relative DA D1 and D2 receptor affinity and efficacy determine whether DA agonists induce hyperactivity or oral stereotypy in rats. Pharmacol.Toxicol. 1988 PMID: 3259694
Product Specific Notices for SKF 81297 hydrobromide
For research use only
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