SKF 81297 hydrobromide

Name: SKF 81297 hydrobromide
Brand: Tocris Bioscience
SKU: 1447
Rating: 5 (1 reviews)

Catalog # 1447 | Tocris Bioscience a Bio-Techne Brand

(1)

Citations (25)

COA / SDS

D1 agonist

Key Product Details

Description:	D₁ agonist
Chemical Name:	(±)-6-Chloro-2,3,4,5-tetrahydro-1-phenyl-1H-3-benzazepine hydrobromide
Purity:	≥98% (HPLC)
Molecular Weight:	370.67

View Full Technical Details for SKF 81297 hydrobromide

Technical Data
Citations (25) / Reviews (1)

Biological Activity for SKF 81297 hydrobromide

SKF 81297 hydrobromide is a dopamine D₁-like receptor agonist. Centrally active following systemic administration in vivo.

Compound Libraries for SKF 81297 hydrobromide

SKF 81297 hydrobromide is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SKF 81297 hydrobromide

M. Wt	370.67
Formula	C₁₆H₁₆ClNO₂.HBr
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	67287-39-2
PubChem ID	11957706
InChi Key	RMIJGBMRNYUZRG-UHFFFAOYSA-N
Smiles	Br.OC1=C(O)C(Cl)=C2CCNCC(C3=CC=CC=C3)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SKF 81297 hydrobromide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	37.07	100
	water	3.71	10 with gentle warming

Preparing Stock Solutions for SKF 81297 hydrobromide

The following data is based on the product molecular weight 370.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.70 mL	13.49 mL	26.98 mL
5 mM	0.54 mL	2.70 mL	5.40 mL
10 mM	0.27 mL	1.35 mL	2.70 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

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References for SKF 81297 hydrobromide

References are publications that support the biological activity of the product.

Reavill Pharmacological characterization of the discriminative stimulus properties of the DA D₁ agonist, SKF 81297. Behav.Pharmacol. 1993 PMID: 11224180
Peacock The effects of DA D₁ and D₂ receptor agonists and antagonists in monkeys withdrawn from long-term neuroleptic treatment. Eur.J.Pharmacol. 1990 PMID: 1980891
Arnt Relative DA D₁ and D₂ receptor affinity and efficacy determine whether DA agonists induce hyperactivity or oral stereotypy in rats. Pharmacol.Toxicol. 1988 PMID: 3259694

Citations for SKF 81297 hydrobromide (25)

Showing 1 - 10 of 25 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for SKF 81297 hydrobromide include:

Dorst et al. (2020) Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner. Nat Commun. 11:5113
PMID: 33037215
Lin et al. (2019) Functional roles of ST8SIA3-mediated sialylation of striatal DA D2 and adenosine A2A receptors. Transl Psychiatry. 9:209
PMID: 31455764
Saika (2018) Chemokine CXCL1 is responsible for cocaine-induced reward in mice. NeurosciPharm Reports. 38(3):145
PMID: 30175527
Guo (2017) DA D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice. Aging Cell. 16(6):1323
PMID: 28975698
Podleśny-Drabiniok et al. (2017) Distinct retinoic acid receptor (RAR) isotypes control differentiation of embryonal carcinoma cells to dopaminergic or striatopallidal medium spiny neurons. Sci Rep. 7:13671
PMID: 29057906
Liu et al. (2017) A Sensitized IGF1 Treatment Restores Corticospinal Axon-Dependent Functions. Neuron. 95:817
PMID: 28817801
Beckley et al. (2016) The First Alcohol Drink Triggers mTORC1-Dependent Synaptic Plasticity in Nucleus Accumbens DA D1 Receptor Neurons. J Neurosci. 36:701
PMID: 26791202
Meunier et al. (2015) Effect of DArgic D1 receptors on plasticity is dependent of serotoninergic 5-HT1A receptors in L5-pyramidal neurons of the prefrontal cortex. PLoS One. 10:e0120286
PMID: 25775449
Pezze et al. (2015) DArgic modulation of appetitive trace conditioning: the role of D1 receptors in medial prefrontal cortex. Mol Med Rep. 232:2669
PMID: 25820982
Parnaudeau et al. (2014) Glucocorticoid receptor gene inactivation in DA-innervated areas selectively decreases behavioral responses to amphetamine. Front Behav Neurosci. 8:35
PMID: 24574986
Cilz et al. (2014) DArgic modulation of GABAergic transmission in the entorhinal cortex: concerted roles of α1 adrenoreceptors, inward rectifier K⁺, and T-type Ca²⁺ channels. Cereb Cortex. 24:3195
PMID: 23843440
Södersten et al. (2014) DA signaling leads to loss of Polycomb repression and aberrant gene activation in experimental parkinsonism. PLoS Genet. 10:e1004574
PMID: 25254549
Spulber et al. (2014) PFOS induces behavioral alterations, including spontaneous hyperactivity that is corrected by dexamfetamine in zebrafish larvae. PLoS One. 9:e94227
PMID: 24740186
Chen et al. (2014) Differential role of D1 and D2 receptors in the perifornical lateral hypothalamus in controlling ethanol drinking and food intake: possible interaction with local orexin neurons. Alcohol Clin Exp Res. 38:777
PMID: 24236888
Marley et al. (2013) GPR88 reveals a discrete function of primary cilia as selective insulators of GPCR cross-talk. Psychopharmacology (Berl). 8:e70857
PMID: 23936473
Guha et al. (2012) Stimulation of the D5 DA receptor acidifies the lysosomal pH of retinal pigmented epithelial cells and decreases accumulation of autofluorescent photoreceptor debris. J Neurochem. 122:823
PMID: 22639870
Olianas et al. (2012) Coincidence signaling of DA D1-like and M1 muscarinic receptors in the regulation of cyclic AMP formation and CREB phosphorylation in mouse prefrontal cortex. Neurosignals. 21:61
PMID: 22456324
Hodas et al. (2012) DArgic modulation of the hippocampal neuropil proteome identified by bioorthogonal noncanonical amino acid tagging (BONCAT). Proteomics. 12:2464
PMID: 22744909
Urizar et al. (2011) CODA-RET reveals functional selectivity as a result of GPCR heteromerization. Nat Neurosci. 7:624
PMID: 21785426
Li et al. (2011) Casein kinase 1 enables nucleus accumbens amphetamine-induced locomotion by regulating AMPA receptor phosphorylation. J Neurochem. 118:237
PMID: 21564097
Krishnan et al. (2011) DA-induced plasticity, phospholipase D (PLD) activity and cocaine-cue behavior depend on PLD-linked metabotropic glutamate receptors in amygdala. PLoS One. 6:e25639
PMID: 21980514
Deng et al. (2010) MeCP2 in the nucleus accumbens contributes to neural and behavioral responses to psychostimulants. PLoS One. 13:1128
PMID: 20711186
Towers and Hestrin (2008) D1-like DA receptor activation modulates GABAergic inhibition but not electrical coupling between neocortical fast-spiking interneurons. J Neurosci. 28:2633
PMID: 18322106
Stramiello (2008) D1/5 receptor-mediated enhancement of LTP requires PKA, Src family kinases, and NR2B-containing NMDARs. Neuropharmacology. 55:871
PMID: 18644393
Floresco and Tse (2007) DArgic regulation of inhibitory and excitatory transmission in the basolateral amygdala-prefrontal cortical pathway. J Neurosci. 27:2045
PMID: 17314300

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SKF81297, a selective D1 receptor agonist.

Name: Xiangping Chu

Species: Human

Assay Type: In Vitro

We used SKF81297 at a concentration of 10 µM/L to active dopamine D1 receptor in cultured mouse striatal neuron.

It is very easy to dissolve the product

There are no reviews that match your criteria.