SKF 81297 hydrobromide

Name: SKF 81297 hydrobromide
Brand: Tocris Bioscience
SKU: 1447
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1447

(1)

Citations (58)

COA / SDS

D1 agonist

Key Product Details

Description:	D₁ agonist
Chemical Name:	(±)-6-Chloro-2,3,4,5-tetrahydro-1-phenyl-1H-3-benzazepine hydrobromide
Purity:	≥98% (HPLC)
Molecular Weight:	370.67

View Full Technical Details for SKF 81297 hydrobromide

Technical Data
Citations / Reviews (1)

Biological Activity for SKF 81297 hydrobromide

SKF 81297 hydrobromide is a dopamine D₁-like receptor agonist. Centrally active following systemic administration in vivo.

Compound Libraries for SKF 81297 hydrobromide

SKF 81297 hydrobromide is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SKF 81297 hydrobromide

M. Wt	370.67
Formula	C₁₆H₁₆ClNO₂.HBr
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	67287-39-2
PubChem ID	11957706
InChi Key	RMIJGBMRNYUZRG-UHFFFAOYSA-N
Smiles	Br.OC1=C(O)C(Cl)=C2CCNCC(C3=CC=CC=C3)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SKF 81297 hydrobromide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	37.07	100
	water	3.71	10 with gentle warming

Preparing Stock Solutions for SKF 81297 hydrobromide

The following data is based on the product molecular weight 370.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.70 mL	13.49 mL	26.98 mL
5 mM	0.54 mL	2.70 mL	5.40 mL
10 mM	0.27 mL	1.35 mL	2.70 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

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Reconstitution Calculator

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References for SKF 81297 hydrobromide

References are publications that support the biological activity of the product.

Peacock The effects of DA D₁ and D₂ receptor agonists and antagonists in monkeys withdrawn from long-term neuroleptic treatment. Eur.J.Pharmacol. 1990 PMID: 1980891
Reavill Pharmacological characterization of the discriminative stimulus properties of the DA D₁ agonist, SKF 81297. Behav.Pharmacol. 1993 PMID: 11224180
Arnt Relative DA D₁ and D₂ receptor affinity and efficacy determine whether DA agonists induce hyperactivity or oral stereotypy in rats. Pharmacol.Toxicol. 1988 PMID: 3259694