SJF 8240

Name: SJF 8240
Brand: Tocris Bioscience
SKU: 7266
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 7266

(1)

Citations (2)

COA / SDS

c-MET PROTAC®; also degrades exon-14-deleted c-MET

Key Product Details

Description:	c-MET PROTAC^®; also degrades exon-14-deleted c-MET
Chemical Name:	N-(3-Fluoro-4-((7-(3-(3-(3-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-3-oxopropoxy)propoxy)propoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	1106.25

View Full Technical Details for SJF 8240

Technical Data
Citations / Reviews (1)

Biological Activity for SJF 8240

SJF 8240 is a c-MET PROTAC^® Degrader. Comprises MET inhibitor foretinib joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. Degrades c-MET within 6 hours in vitro. Inhibits agonist-driven AKT phosphorylation and GTL16 cell proliferation (IC₅₀ = 66.7 nM). Also degrades exon-14-deleted c-MET in Hs746T cells.

c-MET antibodies validated for Western Blot also available: Catalog # AF276 and MAB5694.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data for SJF 8240

M. Wt	1106.25
Formula	C₅₈H₆₅F₂N₇O₁₁S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2230821-68-6
PubChem ID	135175904
InChi Key	SCUZPTNDZHEHLB-ZWUDBOSPSA-N
Smiles	COC1=CC2=C(N=CC=C2OC3=C(C=C(C=C3)NC(C4(C(NC5=CC=C(C=C5)F)=O)CC4)=O)F)C=C1OCCCOCCCOCCC(N[C@@H](C(C)(C)C)C(N6C[C@@H](C[C@H]6C(NCC7=CC=C(C8=C(N=CS8)C)C=C7)=O)O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SJF 8240

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	55.31	50

Preparing Stock Solutions for SJF 8240

The following data is based on the product molecular weight 1106.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	1.81 mL	9.04 mL	18.08 mL
2.5 mM	0.36 mL	1.81 mL	3.62 mL
5 mM	0.18 mL	0.90 mL	1.81 mL
25 mM	0.04 mL	0.18 mL	0.36 mL

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References for SJF 8240

References are publications that support the biological activity of the product.

Burselem The advantages of targeted protein degradation over inhibition: an RTK case study. Cell Chem.Biol. 2018 PMID: 29129716