Sivelestat sodium salt

Tocris Bioscience, part of Bio-Techne | Catalog # 3535

Selective leukocyte elastase inhibitor
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Key Product Details

Description

Selective leukocyte elastase inhibitor

Alternative Names

ONO-5046

View all Synthetic Elastase Inhibitors »

Product Description

Sivelestat sodium salt is a selective leukocyte elastase inhibitor (IC50 = 44 nM) that displays no activity at a range of other proteases. Inhibits NF-κB activation and LTB4-induced neutrophil transmigration in vitro. Significantly attenuates ischemia-induced spinal cord injury, decreases serum cytokine levels and reduces acute inflammatory lung injury in vivo.

Product Specifications

Molecular Weight

456.44

Formula

C20H21N2NaO7S

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

N-{2-[({4-[(2,2-Dimethylpropanoyl)oxy]phenyl}sulfonyl)amino]benzoyl}glycine sodium salt

CAS Number

150374-95-1

PubChem ID

23664980

InChI Key

ZAIFANJZUGNYCK-UHFFFAOYSA-M

SMILES

[Na+].CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC1=CC=CC=C1C(=O)NCC([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.82 50

Preparing Stock Solutions for Sivelestat sodium salt

The following data is based on the product molecular weight 456.44

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.38 mL 21.91 mL 43.82 mL
2.5 mM 0.88 mL 4.38 mL 8.76 mL
5 mM 0.44 mL 2.19 mL 4.38 mL
25 mM 0.09 mL 0.44 mL 0.88 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Sivelestat sodium salt

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Sivelestat sodium salt

For research use only

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