SIS17

Tocris Bioscience, part of Bio-Techne | Catalog # 7969

Selective HDAC11 inhibitor
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Key Product Details

Description

Selective HDAC11 inhibitor

View all Class IV Histone Deacetylase Inhibitors »

Product Description

SIS17 is a selective HDAC11 inhibitor (IC50 = 0.83 μM). Inhibits demyristoylation of serine hydroxymethyl transferase 2 with no detectable activity at other HDAC subtypes. Combination with Oxaliplatin (Cat. No. 2623) increases cytotoxicity to K562 cells; improves survival of Oxaliplatin-treated 769P cells. Cell permeable.

Product Specifications

Molecular Weight

366.61

Formula

C21H38N2OS

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

N'-Hexadecylthiophene-2-carbohydrazide

CAS Number

2374313-54-7

PubChem ID

139035087

InChI Key

HSHXDCVZWHOWCS-UHFFFAOYSA-N

SMILES

O=C(NNCCCCCCCCCCCCCCCC)C=1SC=CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.67 10

Preparing Stock Solutions for SIS17

The following data is based on the product molecular weight 366.61

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.28 mL 136.38 mL 272.77 mL
0.5 mM 5.46 mL 27.28 mL 54.55 mL
1 mM 2.73 mL 13.64 mL 27.28 mL
5 mM 0.55 mL 2.73 mL 5.46 mL

Calculators

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for SIS17

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SIS17

For research use only

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