This compound (the active product of the prodrug SIN-10, molsidomine) acts as a vasodilator and inhibitor of platelet aggregation; longer acting than nitroprusside or nitroglycerin. Decreases myocardial necrosis and reperfusion-induced endothelial dysfunction in models of myocardial ischemia-reperfusion.

Product Specifications

Molecular Weight

206.63

Formula

C₆H₁₁ClN₄O₂

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

Amino-3-morpholinyl-1,2,3-oxadiazolium chloride

CAS Number

16142-27-1

PubChem ID

197942

InChI Key

ZRFWHHCXSSACAW-UHFFFAOYSA-M

SMILES

NC1=C[N+](N2CCOCC2)=NO1.[Cl-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	20.66	100
	DMSO	20.66	100

Preparing Stock Solutions for SIN-1 chloride

The following data is based on the product molecular weight 206.63

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.84 mL	24.20 mL	48.40 mL
5 mM	0.97 mL	4.84 mL	9.68 mL
10 mM	0.48 mL	2.42 mL	4.84 mL
50 mM	0.10 mL	0.48 mL	0.97 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Tanayama Biotransformation of molsidomine (SIN-10), a new anti-anginal agent in rats. Xenobiotica
Nishikawa Inhibition of platelet aggregation and stimulation of guanylate cyclase by an anti-anginal agent molsidomine and its metabolite. J.Pharmacol.Exp.Ther. 1982 PMID: 6118429
Siegfried Cardioprotection and attenuation of endothelial dysfunction by organic nitric oxide donors in myocardial ichemia-reperfusion. J.Pharmacol.Exp.Ther. 1992 PMID: 1738117
Maurice and Heslam Molecular basis of the synergistic inhibition of platelet function by nitrovasodilators and activators of adenylate cyclase: inhibition of cyclic AMP breakdown by cyclic GMP. Mol.Pharmacol. 1990 PMID: 2160060

SIN-1 chloride

Tocris Bioscience, part of Bio-Techne | Catalog # 0756

Key Product Details

Description

Alternative Names

View all Nitric Oxide Donor/Precursor Compounds »

Product Description