SID 26681509

Name: SID 26681509
Brand: Tocris Bioscience
SKU: 3625
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3625

(1)

Citations (6)

COA / SDS

Cathepsin L inhibitor

Key Product Details

Description:	Cathepsin L inhibitor
Chemical Name:	N-[(1,1-Dimethylethoxy)carbonyl]-L-tryptophan-2-[[[2-[(2-ethylphenyl)amino]-2-oxoethyl]thio]carbonyl]hydrazide
Purity:	≥97% (HPLC)
Molecular Weight:	539.65

View Full Technical Details for SID 26681509

Technical Data
Citations / Reviews (1)

Biological Activity for SID 26681509

SID 26681509 is a potent and reversible human cathepsin L inhibitor (IC₅₀ = 56 nM). Displays no inhibitory activity at cathepsin G. Antimalarial; inhibits leishmaniasis.

Compound Libraries for SID 26681509

SID 26681509 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SID 26681509

M. Wt	539.65
Formula	C₂₇H₃₃N₅O₅S
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	958772-66-2
PubChem ID	16725315
InChi Key	OTIWAYTTYNFEKL-QFIPXVFZSA-N
Smiles	O=C(NNC(SCC(NC1=C(CC)C=CC=C1)=O)=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(OC(C)(C)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SID 26681509

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	26.98	50
	ethanol	5.4	10

Preparing Stock Solutions for SID 26681509

The following data is based on the product molecular weight 539.65.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.71 mL	18.53 mL	37.06 mL
2.5 mM	0.74 mL	3.71 mL	7.41 mL
5 mM	0.37 mL	1.85 mL	3.71 mL
25 mM	0.07 mL	0.37 mL	0.74 mL

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Reconstitution Calculator

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References for SID 26681509

References are publications that support the biological activity of the product.

Myers Identification and synthesis of a unique thiocarbazate cathepsin L inhibitor. Bioorg.Med.Chem.Lett. 2008 PMID: 18060772
Shah Kinetic characterization and molecular docking of a novel, potent and selective slow-binding inhibitor of human cathepsin L. Mol.Pharmacol. 2008 PMID: 18403718