SGC CAMKK2-1

Name: SGC CAMKK2-1
Brand: Tocris Bioscience
SKU: 7877

Tocris Bioscience, part of Bio-Techne | Catalog # 7877

COA / SDS

Potent and selective CAMKK1/2 inhibitor

Key Product Details

Description:	Potent and selective CAMKK1/2 inhibitor
Chemical Name:	2-Cyclopentyl-4-[5-(3-methylphenyl)furo[2,3-b]pyridin-3-yl]benzoic acid
Purity:	≥95% (HPLC)
Molecular Weight:	397.47

View Full Technical Details for SGC CAMKK2-1

Technical Data
Citations

Biological Activity for SGC CAMKK2-1

SGC CAMKK2-1 is a potent and selective Ca²⁺-calmodulin-dependent protein kinase kinase (CaMKK) inhibitor (CAMKK2 IC₅₀ = 30 nM). Displays selectivity toward CAMKK1 and CAMKK2 over 404 kinases in a kinome wide screen (Discoverx). SGC CAMKK2-1 inhibits AMPK phosphorylation in C4-2 prostate cancer cells (IC₅₀ = 1.6 μM).

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the SGC CAMKK2-1 probe summary on the SGC website.

Technical Data for SGC CAMKK2-1

M. Wt	397.47
Formula	C₂₆H₂₃NO₃
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2561494-76-4
PubChem ID	154700451
InChi Key	TXIYVFVMXNFNRX-UHFFFAOYSA-N
Smiles	O=C(C1=C(C2CCCC2)C=C(C3=COC4=NC=C(C5=CC(C)=CC=C5)C=C43)C=C1)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SGC CAMKK2-1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	39.75	100

Preparing Stock Solutions for SGC CAMKK2-1

The following data is based on the product molecular weight 397.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.52 mL	12.58 mL	25.16 mL
5 mM	0.50 mL	2.52 mL	5.03 mL
10 mM	0.25 mL	1.26 mL	2.52 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

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References for SGC CAMKK2-1

References are publications that support the biological activity of the product.