SET 2
Tocris Bioscience, part of Bio-Techne | Catalog # 6990
Selective TRPV2 antagonist
Product Description
SET 2 is a TRPV2 (transient receptor potential vanilloid type 2) antagonist (IC50 = 0.46 μM). Selective for TRPV2 over TRPV1, TRPV3 and TRPV4 expressed in HEK293 cells. Inhibits lyosphosphatidic acid (LPA)-induced prostate cancer cell migration in vitro.Product Specifications
Molecular Weight
402.44
Formula
C17H21F3N4O2S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-(2-Furanylmethyl)-3-[[4-(methylpropylamino)-6-(trifluoromethyl)-2-pyrimidinyl]thio]propanamide
CAS Number
2313525-20-9
InChI Key
LZHSWRWIMQRTOP-UHFFFAOYSA-N
SMILES
CCCN(C1=NC(SCCC(NCC2=CC=CO2)=O)=NC(C(F)(F)F)=C1)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.24 | 100 | |
| Ethanol | 20.12 | 50 |
Preparing Stock Solutions
for SET 2
The following data is based on the product molecular weight 402.44
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.48 mL | 12.42 mL | 24.85 mL |
| 5 mM | 0.50 mL | 2.48 mL | 4.97 mL |
| 10 mM | 0.25 mL | 1.24 mL | 2.48 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.50 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Chai Structure-based discovery of a subtype-selective inhibitor targeting a transient receptor potential vanilloid channel. J.Med.Chem. 2019 PMID: 30620187
Product Specific Notices for SET 2
For research use only
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