Sephin 1

Name: Sephin 1
Brand: Tocris Bioscience
SKU: 5553

Tocris Bioscience, part of Bio-Techne | Catalog # 5553

Citations (3)

COA / SDS

Inhibitor of the regulatory subunit PPP1R15A of protein phosphatase 1

Key Product Details

Description:	Inhibitor of the regulatory subunit PPP1R15A of protein phosphatase 1
Chemical Name:	(2E)-2-[(2-Chlorophenyl)methylene]-hydrazinecarboximidamide carbonic acid salt
Purity:	≥98% (HPLC)
Molecular Weight:	258.66

View Full Technical Details for Sephin 1

Technical Data
Citations

Biological Activity for Sephin 1

Sephin 1 is an inhibitor of the regulatory subunit PPP1R15A of protein phosphatase 1. Does not bind PPP1R15B or have α2 adrenergic agonist activity. Cytoprotective in endoplasmic reticulum stressed cells in vitro. Prevents defects associated with protein misfolding in a mouse Charcot-Marie Tooth-1B model. Orally available.

Compound Libraries for Sephin 1

Sephin 1 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for Sephin 1

M. Wt	258.66
Formula	C₈H₉ClN₄.CH₂O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1883549-35-6
PubChem ID	121513868
InChi Key	LCQVFBONUDQAEH-NKPNRJPBSA-N
Smiles	ClC1=C(/C=N/NC(N)=N)C=CC=C1.OC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Sephin 1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	25.87	100

Preparing Stock Solutions for Sephin 1

The following data is based on the product molecular weight 258.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.87 mL	19.33 mL	38.66 mL
5 mM	0.77 mL	3.87 mL	7.73 mL
10 mM	0.39 mL	1.93 mL	3.87 mL
50 mM	0.08 mL	0.39 mL	0.77 mL

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References for Sephin 1

References are publications that support the biological activity of the product.

Das Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit. Science 2015 PMID: 25859045