Semaglutide New

Name: Semaglutide
Brand: Tocris Bioscience
SKU: 8946

Tocris Bioscience, part of Bio-Techne | Catalog # 8946

COA / SDS

Highly potent, long-acting GLP-1 receptor agonist

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Technical Data
Citations

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Highly potent, long-acting GLP-1 receptor agonist

Alternative Names

NN-9535,NNC0480-0389

View all Glucagon-Like Peptide 1 Receptor Agonists »

Product Description

Semaglutide is a glucon-like peptide 1 analog and a potent and long-acting GLP-1R agonist. Upon activating GLP-1R, Semaglutide promotes insulin secretion, inhibits gastric emptying and appetite, causing lasting and reversible weight loss in normal and obese rats. Enhances autophagy by increasing the expression of LC3II, Atg7, Beclin-1 and P62; inhibits oxidative stress and apoptosis. Semaglutide has neuroprotective properties in a stroke animal model, where neurogenesis and growth factor cell signaling is normalized. Can be used for the study of neurodegenerative diseases and liver diseases such as type 2 diabetes, obesity, Parkinson's disease, metabolic associated fatty liver disease (MASLD), and cancer.

Product Specifications

Molecular Weight

4113.64

Formula

C₁₈₇H₂₉₁N₄₅O₅₉

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

910463-68-2

PubChem ID

154733530

InChI Key

DLSWIYLPEUIQAV-CIIFZSTISA-N

SMILES

CC[C@@H]([C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](C(C)C)C(N[C@H](C(NCC(N[C@H](C(NCC(O)=O)=O)CCCNC(N)=N)=O)=O)CCCNC(N)=N)=O)=O)CC(C)C)=O)CC1=CNC2=C1C=CC=C2)=O)C)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](C(C)C)NC([C@@H](NC([C@@H](NC([C@H]([C@H](O)C)NC([C@@H](NC([C@H]([C@H](O)C)NC(CNC([C@@H](NC(C(C)(NC([C@H](CC3=CNC=N3)N)=O)C)=O)CCC(O)=O)=O)=O)=O)CC4=CC=CC=C4)=O)=O)CO)=O)CC(O)=O)=O)=O)CO)=O)CO)=O)CC5=CC=C(C=C5)O)=O)CC(C)C)=O)CCC(O)=O)=O)=O)CCC(N)=O)=O)C)=O)C)=O)CCCCNC(COCCOCCNC(COCCOCCNC(CC[C@@H](C(O)=O)NC(CCCCCCCCCCCCCCCCC(O)=O)=O)=O)=O)=O)=O)CCC(O)=O)=O)CC6=CC=CC=C6)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

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Background References

References are publications that support the biological activity of the product.

Mahapatra Therapeutic potential of semaglutide, a newer GLP-1 receptor agonist, in abating obesity, non-Alcoholic steatohepatitis and neurodegenerative diseases: a narrative review. Pharm.Res. 2022 PMID: 35650449
Yang The diabetes drug semaglutide reduces infarct size, inflammation, and apoptosis, and normalizes neurogenesis in a rat model of stroke. Neuropharmacology 2019 PMID: 31465784
Chang Semaglutide-mediated protection against Aβ correlated with enhancement of autophagy and inhibition of apoptosis. J.Clin.Neurosc. 2020 PMID: 33222922
Gabery Semaglutide lowers body weight in rodents via distributed neural pathways. JCl Insight 2020 PMID: 32213703
Lau Discovery of the once-weekly glucagon-like peptide-1 (GLP-1) analogue semaglutide. J.Med.Chem 2015 PMID: 26308095
Knudsen The discovery and development of liraglutide and semaglutide. Front.Endocrinol. 2019 PMID: 31031702