SDZ WAG 994
Tocris Bioscience, part of Bio-Techne | Catalog # 2465
Potent and selective A1 agonist
Key Product Details
Description
Potent and selective A1 agonist
Product Description
SDZ WAG 994 is a potent and selective A1 adenosine receptor agonist (Ki values are 23, > 10000 and 25000 nM for A1, A2A and A2B receptors respectively). Causes a sustained fall in blood pressure and heart rate in spontaneous hypertensive rats and inhibits adenosine deaminase-stimulated lipolysis in rat adipocytes (Ki = 8 nM).Product Specifications
Molecular Weight
363.41
Formula
C17H25N5O4
Storage
Desiccate at +4°C
Purity
≥99% (HPLC)
Chemical Name
N-Cyclohexyl-2'-O-methyladenosine
CAS Number
130714-47-5
PubChem ID
164305
InChI Key
JAKAFSGZUXCHLF-LSCFUAHRSA-N
SMILES
O[C@@H]1[C@@H](CO)O[C@@H](N(C=N4)C2=C4C(NC3CCCCC3)=NC=N2)[C@@H]1OC
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1.1eq. NaOH | 36.34 | 100 | |
| DMSO | 36.34 | 100 |
Preparing Stock Solutions
for SDZ WAG 994
The following data is based on the product molecular weight 363.41
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.75 mL | 13.76 mL | 27.52 mL |
| 5 mM | 0.55 mL | 2.75 mL | 5.50 mL |
| 10 mM | 0.28 mL | 1.38 mL | 2.75 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.55 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Jacobson and Gao Adenosine receptors as therapeutic targets. Nat.Rev.Drug Discov. 2006 PMID: 16518376
- Wagner General pharmacology of SDZ WAG 994, a potent selective and orally active adenosine A1 receptor agonist. Drug Dev.Res.
- Ishikawa Hypoglycemic and hypotensive effects of 6-cyclohexyl-2'-O-methyl-adenosine, an adenosine A1 receptor agonist, in spontaneous hypertensive rat complicated with hyperglycemia. Diabetes Res.Clin.Pract. 1998 PMID: 9597368
Product Specific Notices for SDZ WAG 994
For research use only
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